HAFT-1 mouse

eagle-i ID

Resource Type

Properties

1. Resource Description

   Used to study alcoholism; acute functional tolerance to alcohol. Embryo cryopreserved. High Acute Functional Tolerance -1. Selectively bred line.

2. Contact

   Metten, Pamela, Ph.D.

3. Inventory Number

   MMRRC:030752-UCD

4. Related Disease

   alcohol abuse

5. Related Publication or Documentation

   Genetic Selection and Characterization of Mouse Lines for Acute Functional Tolerance to Ethanol

6. Website(s)

   http://www.mmrrc.org/catalog/StrainCatalogSearchForm.jsp

7. Website(s)

   http://www.ohsu.edu/parc/animal_models.htm

8. Related Technique

   Behavioral assay

9. Parental Strain Name

   HS/Ibg 8-way inbred strain cross

10. Phenotype Findings

    Display high acute functional tolerance to ethanol, calculated as the difference in blood ethanol concentrations at the time of regaining the ability to stay for 1 minute on a stationary dowel (12.7 mm) after two consecutive injections of ethanol (1.75 g/ kg followed by 2.0 g/kg, IP).

11. Location

    Portland Alcohol Research Center