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Crabbe, John C., Ph.D.

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Resource Type

  1. Person


  1. Resource Description
    "I have developed mouse pharmacogenetic models for sensitivity to and dependence on ethanol by selectively breeding lines of mice resistant, or susceptible, to the severity of withdrawal from ethanol dependence. With my collaborators I am analyzing the neurobiological mechanisms underlying the large differences between the Withdrawal Seizure-Prone and -Resistant lines. These studies are concentrated on the neuropharmacological mechanisms leading to alcohol withdrawal convulsions, on their differential susceptibility to other drugs of abuse, and on developing a more comprehensive set of behavioral assays characterizing withdrawal severity. Other approaches include studies of multiple inbred and recombinant strains of mice examining the basis for genetic correlations between susceptibilities to different drugs of abuse. These studies are exploring the specificity of genetic influences across different environments, including multiple laboratories. They are also intended to elucidate gene-environment interactions. Strain patterns of sensitivity sometimes indicate the important influence of single genes on drug responses. Using statistical techniques for mapping Quantitative Trait Loci (QTLs), my collaborators are identifying and mapping specific major and minor genes of importance. We are beginning to identify candidate genes for particular QTLs, and are developing congenic strains by genotypic (marker-based) selection for certain QTLs of pleiotropic importance. We are also developing new lines of mice selectively bred for binge Drinking in the Dark as a part of the Integrative Neuroscience Initiative on Alcoholism (INIA-West) consortium. These mice drink to the point of intoxication, reaching average blood levels higher than the legal driving limit. We are exploring the pharmacological characteristics of the neural circuitry underlying this drinking."
  2. First Name
  3. Last Name
  4. Title
    Director, Portland Alcohol Research Center
  5. Title
  6. Performs Technique
    Behavioral assay
  7. Website(s)
  8. Website(s)
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