eagle-i Oregon Health & Science UniversityOregon Health & Science University
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

FLT3: AML mutation testing

eagle-i ID

http://ohsu.eagle-i.net/i/0000012b-00ce-c09c-79a3-37368000001b

Resource Type

  1. Material analysis service

Properties

  1. Resource Description
    "Kinase activating mutations of the FLT3 gene occur in a significant subset of acute myelogenous leukemias (AMLs) and confer a poor prognosis. The most common mutation (and the one detected in our lab) is an internal tandem duplication (ITDs) in exon 11 of the FLT3 gene (juxtamembrane domain), present in ~20-30% of all AMLs. If present, novel targeted therapies directed at this activated tyrosine kinase may be of clinical benefit."
  2. Resource Description
    "Other terms: AML: acute myelogenous leukemias PCR-based study Tyrosine kinase gene Exon 11 of the FLT3 gene Juxtamenbrane domaine"
  3. Resource Description
    "Specimen: ACD or EDTA whole blood; Bone marrow (fresh, unfixed) Handling: Transport at room temperature to arrive at the Molecular Diagnostic Center within 24 hours; if sample cannot arrive within 24 hours, refrigerate until sample can be transported, then transport at room temperature. Special Requirement: In order to detect FLT3 mutations, acceptable specimens of blood or bone marrow must have a minimum of 20% blast cells. Samples with less than 20% blasts will not be analyzed. A copy of the CBC w/diff or a Hematopathology report showing blast cell load would be ideal."
  4. Resource Description
    "Synonyms: FLT, FLT3, AML mutation, ITD (internal tandem duplications) mutation, FLT3 mutation"
  5. Additional Name
    FLT3: acute myelogenous leukemias mutation testing
  6. Contact
    Richards, Carolyn Sue, PhD
  7. Service Provided by
    Molecular Diagnostic Center
  8. Website(s)
    http://www.ohsu.edu/pathology/wardman/forms/flt3info.pdf
 
RDFRDF
 
Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016