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Haigwood, Nancy, Ph.D.

eagle-i ID

http://ohsu.eagle-i.net/i/0000012b-36a0-d830-62b8-f47280000000

Resource Type

  1. Person

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  1. Resource Description
    "Dr. Haigwood's laboratory has a long-standing interest in structure-function studies of recombinant glycoproteins that has led to a current focus in three overlapping areas of research: 1) neutralizing antibodies (NAbs) directed to the HIV and SIV Envelope (Env) glycoproteins; 2) mother-to-child transmission (MTCT) of HIV/SIV; and 3) HIV vaccine development. Env-glycoproteins play a major role in immunity and host defense in the primate lentiviruses. Her group has investigated the role of SIV and HIV Envelope-specific NAbs in immune control and as potential therapeutic entities in nonhuman primate (NHP) models. Her group showed in 1991 that NAbs in humans with broad activity are directed to conformational determinants. In the SIV system, the group found that time to disease was significantly lengthened by passive treatment with NAbs (IgG) during acute infection. Better outcome correlated with maintenance of low virus load and the development of antiviral immunity. Importantly, the presence of NAbs during acute infection accelerated the development of effective NAbs, a novel finding that has implications for both vaccines and for therapies."
  2. First Name
    Nancy
  3. Last Name
    Haigwood
  4. Title
    Adjunct Professor, Department of Molecular Microbiology & Immunology
  5. Title
    ONPRC Director
  6. Title
    Senior scientist
  7. Website(s)
    http://www.ohsu.edu/vgti/haigwood.htm
  8. Website(s)
    http://www.ohsu.edu/xd/research/centers-institutes/onprc/scientific-discovery/scientists/nancy-haigwood.cfm
 
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