Reagent
reagent
reagent
Fibrinogen gamma' peptide as an anticoagulant
http://www.ohsu.edu/tech-transfer/portal/technology.php?technology_id=19055
Website(s)
has URL
has_url
Inventors:
David Farrell and
Rehana Lovely
Resource Description
resource_description
"The anticoagulant (Gammarin) is a synthetic peptide that corresponds in amino acid sequence to the carboxyl terminal 18 amino acids in the g' chain of the blood clotting factor fibrinogen, PEHPAETEYDSLYPEDDL, but contains phosphotyrosine residues in place of the natural sulfotyrosine residues at amino acids 9 and 13 (equivalent to amino acids 418 and 422 in the native g' chain). Gammarin binds to exosite II on thrombin (Lovely 2003; Sabo 2006), similar to heparin, but unlike heparin, Gammarin inhibits the action of thrombin even in the absence of the natural thrombin inhibitor antithrombin III. We have shown that Gammarin inhibits thrombosis in a baboon model (Lovely 2007), and prevents activation of hemophilia factor A (factor VIII), while allowing normal platelet adhesion for primary hemostasis."
Related Publication or Documentation
has documentation
has_documentation
Fibrinogen gamma' chain binds thrombin exosite II.
Fibrinogen gamma' chain carboxy terminal peptide selectively inhibits the intrinsic coagulation pathway.
Conformational analysis of gamma' peptide (410-427) interactions with thrombin anion binding exosite II.
Contact
has contact
has_contact
Farrell, David H., Ph.D.
Related Technique
related technique
ELISA
related_technique
ELISA
Location
located_in
David H. Farrell Laboratory
located in
2010-09-22T15:30:20.465-05:00
pjakobs (Petra Jakobs)
2011-04-25T17:09:45.010-05:00
workflow state
Published
nvasilevsky (Nicole Vasilevsky)
processed material
processed material
material_entity
independent_continuant
continuant
entity