eagle-i Oregon Health & Science UniversityOregon Health & Science University
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Liskay, R. Michael, Ph.D.

eagle-i ID

http://ohsu.eagle-i.net/i/0000012b-a734-8b0f-62b8-f47280000000

Resource Type

  1. Person

Properties

  1. Resource Description
    "We use yeast and mice to study DNA mismatch repair (MMR),which corrects mismatches and senses DNA damage. MMR gene mutations increase spontaneous mutation and predispose to hereditary and sporadic cancer. Using gene targeting strategies, we derive and study knockout mice for four MutL homologs, Mlh1, Pms1 or Pms2, and Mlh3. We have observed increased mutation and cancer risk in these animals although the severity varies between the different knockouts. In a related project, we have developed an assay using the site-specific recombinase Cre to stochastically inactivate tumor suppressor genes or activate oncogenes in the mouse. The system also uses a color marker (b-galactosidase) which is activated by the recombinase thus marking those celllineages experiencing inactivation (or activation) of the "loxp"-tagged tumor suppressors/oncogenes. One question being addressed is "What is the minimum number of gene alterations necessary to promote intestinal tumor formation and progression in the mouse?" Our studies in yeast are centered on a better understanding of mechanism and the gene products involved in DNA mismatch repair."
  2. First Name
    Robert Michael (Mike)
  3. Last Name
    Liskay
  4. Title
    Professor of Molecular & Medical Genetics
  5. Website(s)
    http://www.ohsu.edu/xd/education/schools/school-of-medicine/departments/basic-science-departments/molecular-and-medical-genetics/people/primary-faculty/r-michael-liskay.cfm?WT_rank=1
 
RDFRDF
 
Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016