eagle-i Oregon Health & Science UniversityOregon Health & Science University
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Pms2 Knockout mouse

eagle-i ID

http://ohsu.eagle-i.net/i/0000012b-c103-e36d-58a2-5e9f80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Mutations in the DNA mismatch repair pathway have been shown to be involved in the development of certain cancers. PMS2 is one of the genes involved in the DNA mismatch/repair pathway. PMS2 knock-out mice and cell lines provide a novel model to study cancer and could potentially aid in the development of new therapeutics for oncology. Licensing and collaborative research opportunities exist with respect to these biological materials. PMS2 is a weak mutator, the PMS control A12 has been engineered by adding an A onto the CRE. If a reversion to A11 occurs the Beta gal or Lacz reporter indicates an event of reversion. Such an event may turn over time into a tumor that warrants further characterization.
  2. Contact
    Dudley, Sandra
  3. Related Disease
    cancer
  4. Related Publication or Documentation
    Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I.
  5. Parental Strain Name
    C57Bl/6J
  6. Genetic Alteration(s)
    Pms2 knockout
  7. Phenotype Findings
    Tumorigenic
  8. Location
    Michael Liskay Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016