Pms2 Knockout mouse

eagle-i ID

Resource Type

Properties

1. Resource Description

   Mutations in the DNA mismatch repair pathway have been shown to be involved in the development of certain cancers. PMS2 is one of the genes involved in the DNA mismatch/repair pathway. PMS2 knock-out mice and cell lines provide a novel model to study cancer and could potentially aid in the development of new therapeutics for oncology. Licensing and collaborative research opportunities exist with respect to these biological materials. PMS2 is a weak mutator, the PMS control A12 has been engineered by adding an A onto the CRE. If a reversion to A11 occurs the Beta gal or Lacz reporter indicates an event of reversion. Such an event may turn over time into a tumor that warrants further characterization.

2. Contact

   Dudley, Sandra

3. Related Disease

   cancer

4. Related Publication or Documentation

   Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I.

5. Parental Strain Name

   C57Bl/6J

6. Genetic Alteration(s)

   Pms2 knockout

7. Phenotype Findings

   Tumorigenic

8. Location

   Michael Liskay Laboratory