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Mlh1-Deficient Mice

eagle-i ID

http://ohsu.eagle-i.net/i/0000012b-c13e-d9ed-58a2-5e9f80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    MLH1 is one of the genes involved in DNA repair during cell division. MLH1 knock-out mice and cell lines provide a novel model to study cancer and could potentially aid in the development of new therapeutics for oncology. Licensing and collaborative research opportunities exist with respect to these biological materials. In humans, most germline mutation carriers are heterozygotes (+/-) carrying recessive MLH1 mutations in all tissues. When the other MLH1 gene is inactivated in a particular cell, in the lining of the colon for example, the mutation rate in that cell and its progenitors increases dramatically, mutations accumulate and tumors can arise.
  2. Contact
    Dudley, Sandra
  3. Related Disease
    colon cancer
  4. Related Publication or Documentation
    Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6.
  5. Parental Strain Name
    C57BL/6
  6. Genetic Alteration(s)
    Mlh1 knockout
  7. Phenotype Findings
    Increased spontaneous mutations throughout the genome
  8. Location
    Michael Liskay Laboratory
 
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Provenance Metadata About This Resource Record

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016