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Pms2 cre Apc fx conditional knockout mice

eagle-i ID

http://ohsu.eagle-i.net/i/0000012b-eab3-cd0b-db67-de4080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    DNA mismatch repair (MMR) leads to an increased mutation frequency and a predisposition to neoplasia. Knockout mice deficient in the MMR proteins PMS2 crossed with mutation detection reporter (supF) transgenic mice have been used to facilitate a comparison of the changes in mutation frequency and spectra. PMS2 -deficient mice accumulate transition mutations as the predominant mutation. Both male and female mice are available.
  2. Related Disease
    colon cancer
  3. Related Publication or Documentation
    Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice.
  4. Related Publication or Documentation
    Different Phenotypic Consequences of Simultaneous Versus Stepwise Apc Loss
  5. Parental Strain Name
    C57BL/6
  6. Genetic Alteration(s)
    Pms2 knockout
  7. Genetic Alteration(s)
    supF insertion
  8. Phenotype Findings
    Severe cancer phenotype
  9. Location
    Michael Liskay Laboratory
 
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