Pms2 cre Apc fx conditional knockout mice

eagle-i ID

Resource Type

Properties

1. Resource Description

   DNA mismatch repair (MMR) leads to an increased mutation frequency and a predisposition to neoplasia. Knockout mice deficient in the MMR proteins PMS2 crossed with mutation detection reporter (supF) transgenic mice have been used to facilitate a comparison of the changes in mutation frequency and spectra. PMS2 -deficient mice accumulate transition mutations as the predominant mutation. Both male and female mice are available.

2. Related Disease

   colon cancer

3. Related Publication or Documentation

   Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice.

4. Related Publication or Documentation

   Different Phenotypic Consequences of Simultaneous Versus Stepwise Apc Loss

5. Parental Strain Name

   C57BL/6

6. Genetic Alteration(s)

   Pms2 knockout

7. Genetic Alteration(s)

   supF insertion

8. Phenotype Findings

   Severe cancer phenotype

9. Location

   Michael Liskay Laboratory