eagle-i Oregon Health & Science UniversityOregon Health & Science University
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Pms2 cre Apc fx conditional knockout mice

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    DNA mismatch repair (MMR) leads to an increased mutation frequency and a predisposition to neoplasia. Knockout mice deficient in the MMR proteins PMS2 crossed with mutation detection reporter (supF) transgenic mice have been used to facilitate a comparison of the changes in mutation frequency and spectra. PMS2 -deficient mice accumulate transition mutations as the predominant mutation. Both male and female mice are available.
  2. Related Disease
    colon cancer
  3. Related Publication or Documentation
    Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice.
  4. Related Publication or Documentation
    Different Phenotypic Consequences of Simultaneous Versus Stepwise Apc Loss
  5. Parental Strain Name
  6. Genetic Alteration(s)
    Pms2 knockout
  7. Genetic Alteration(s)
    supF insertion
  8. Phenotype Findings
    Severe cancer phenotype
  9. Location
    Michael Liskay Laboratory
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016