eagle-i Oregon Health & Science UniversityOregon Health & Science University
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Rosalie Sears Laboratory

eagle-i ID


Resource Type

  1. Laboratory


  1. Resource Description
    "We are studying cellular signaling pathways involved in the generation of human cancer. In general, disruption of these pathways alters the ability of a cell to control its proliferation as well as the initiation of programmed cell death (apoptosis). We are focusing on three key signaling pathways that regulate both cellular proliferation and apoptosis: the Myc transcription factor, the Ras signaling protein, and the G1 cyclin dependent kinase (Cdk)/retinoblastoma(Rb)/E2F pathway. While each of these pathways has been extensively studied over the past decade, the nature of their interrelations remains elusive. Since these pathways are deregulated in the majority of all human tumors, we want to understand how they network and synergize to precisely control cellular proliferation versus cell death. This information will contribute to our understanding of the complex nature of cancer progression, and facilitate the generation of meaningful therapies."
  2. Additional Name
    Rosie Sears Laboratory
  3. Contact
    Sears, Rosalie, Ph.D.
  4. Contact
    Taylor, Karyn
  5. PI
    Sears, Rosalie, Ph.D.
  6. Affiliation
    Department of Molecular & Medical Genetics, Oregon Health & Science University
  7. Website(s)
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016