Andras Gruber Laboratory

eagle-i ID

Resource Type

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1. Resource Description

   "Current Research Goals: To determine the role of contact activation in acute intraluminal thrombus propagation using synthetic vascular grafts in a primate model of thrombosis and hemostasis. If the functionality of the contact system enzyme complex (FXI/FXII/KK/HMWK) is relevant to the pathogenesis of thrombosis, a FXI inhibitor could become the first safe antithrombotic agent. To characterize the effects of endogenous protein C activation on acute arterial thrombogenesis and hemostasis using rationally engineered recombinant enzymes. A pharmacologically viable protein C activator could help utilize the body's own antithrombotic and antiinflammatory system similar to the way streptokinase and tPA became useful fibrinolysis activators."

2. Contact

   Gruber, Andras, M.D.

3. PI

   Gruber, Andras, M.D.

4. Affiliation

   Department of Biomedical Engineering

5. Website(s)

   http://www.ohsu.edu/xd/education/schools/school-of-medicine/academic-programs/graduate-studies/faculty/grad-studies-faculty.cfm?facultyid=423&WT_rank=2