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p75NTR-/- mice

eagle-i ID

http://ohsu.eagle-i.net/i/0000012f-74a0-fede-f561-6e8a80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "B6.129S4- Ngfrtm1Jae/J mice contain two mutated exon III alleles, which removes the coding region for the last three of four cysteine-rich repeats in the extracellular domain and prevents the expression of functional p75NTR." From Jackson Labs.
  2. Additional Name
    B6.129S4- Ngfrtm1Jae/J
  3. Related Disease
    heart disease
  4. Related Publication or Documentation
    Explant of stellate ganglia protocol
  5. Related Publication or Documentation
    Heterogeneous ventricular sympathetic innervation, altered beta-adrenergic receptor expression, and rhythm instability in mice lacking the p75 neurotrophin receptor.
  6. Related Publication or Documentation
    Altered atrial neurotransmitter release in transgenic p75(-/-) and gp130 KO mice.
  7. Parental Strain Name
    B6.129S4
  8. Phenotype Findings
    Increased spontaneous ventricular arrhythmias
  9. Location
    Beth A. Habecker Laboratory
 
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