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p75NTR-/- mice
eagle-i ID
http://ohsu.eagle-i.net/i/0000012f-74a0-fede-f561-6e8a80000000
Resource Type
Mus musculus
Properties
Resource Description
"B6.129S4- Ngfrtm1Jae/J mice contain two mutated exon III alleles, which removes the coding region for the last three of four cysteine-rich repeats in the extracellular domain and prevents the expression of functional p75NTR." From Jackson Labs.
Additional Name
B6.129S4- Ngfrtm1Jae/J
Related Disease
heart disease
Related Publication or Documentation
Explant of stellate ganglia protocol
Related Publication or Documentation
Heterogeneous ventricular sympathetic innervation, altered beta-adrenergic receptor expression, and rhythm instability in mice lacking the p75 neurotrophin receptor.
Related Publication or Documentation
Altered atrial neurotransmitter release in transgenic p75(-/-) and gp130 KO mice.
Parental Strain Name
B6.129S4
Phenotype Findings
Increased spontaneous ventricular arrhythmias
Location
Beth A. Habecker Laboratory
Inferred Types from the eagle-i Ontology (
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entity
continuant
independent_continuant
material_entity
Organism
Mus <mouse, genus>
Glires
Mammalia
Chordata
Vertebrata <Metazoa>
Rodentia
Organism or Virus
Thing
Provenance Metadata About This Resource Record
workflow state
Published
contributor
shoffmann (Scott Hoffmann)
contributor
nvasilevsky (Nicole Vasilevsky)
created
2011-04-20T15:36:56.347-05:00
creator
shoffmann (Scott Hoffmann)
modified
2012-12-06T19:45:11.935-06:00