gp130 DBH-Cre/lox mice

eagle-i ID

Resource Type

Properties

1. Resource Description

   gp130 is the cytokine receptor subunit that is essential for the action of all IL-6 cytokine family members. Need MTA from Hermann Rohrer (Max Plank Frankfurt).

2. Additional Name

   gp130 Dopamine beta hydroxylase-Cre/lox mice

3. Related Disease

   sweat gland disease

4. Related Publication or Documentation

   Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp130 signaling

5. Related Publication or Documentation

   Altered atrial neurotransmitter release in transgenic p75(-/-) and gp130 KO mice.

6. Related Technique

   Western blot analysis

7. Parental Strain Name

   C57Bl/6

8. Genetic Alteration(s)

   Conditional gp130 knockout

9. Phenotype Findings

   Reduced number of VAChT- and VIP-positive neurons in the sympathetic stellate ganglion

10. Location

    Beth A. Habecker Laboratory