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gp130 DBH-Cre/lox mice

eagle-i ID

http://ohsu.eagle-i.net/i/0000012f-74a2-149f-f561-6e8a80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    gp130 is the cytokine receptor subunit that is essential for the action of all IL-6 cytokine family members. Need MTA from Hermann Rohrer (Max Plank Frankfurt).
  2. Additional Name
    gp130 Dopamine beta hydroxylase-Cre/lox mice
  3. Related Disease
    sweat gland disease
  4. Related Publication or Documentation
    Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp130 signaling
  5. Related Publication or Documentation
    Altered atrial neurotransmitter release in transgenic p75(-/-) and gp130 KO mice.
  6. Related Technique
    Western blot analysis
  7. Parental Strain Name
    C57Bl/6
  8. Genetic Alteration(s)
    Conditional gp130 knockout
  9. Phenotype Findings
    Reduced number of VAChT- and VIP-positive neurons in the sympathetic stellate ganglion
  10. Location
    Beth A. Habecker Laboratory
 
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