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Cath.a cells
eagle-i ID
http://ohsu.eagle-i.net/i/0000012f-8eda-e0cb-fb77-395980000000
Resource Type
Properties
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Resource Description
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"Brain (CATH.a)... cell lines have been established that synthesize abundant dopamine and norepinephrine and express the appropriate catecholaminergic biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase. The line [was] derived from TH-positive tumors in transgenic mice carrying the SV40 T antigen oncogene under the transcriptional control of 773 base pairs of 5' flanking sequences from the rat TH gene. Although the lines continue to express T antigen, they exhibit neuronal properties such as neurofilaments and synaptophysin and lack glial intermediate filaments. Although in vivo TH is only expressed in postmitotic neurons in the CNS, the CATH.a line demonstrates that TH expression and continued cell division are not incompatible after oncogenic transformation."
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Related Publication or Documentation
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Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice.
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Source Organism Type
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Mus musculus
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Developed by
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Chikaraishi, Dona
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Location
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Beth A. Habecker Laboratory