Path.1 cells

eagle-i ID

Resource Type

Properties

1. Resource Description

   "Adrenal (PATH.1) cell lines have been established that synthesize abundant dopamine and norepinephrine and express the appropriate catecholaminergic biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase. The line [was] derived from TH-positive tumors in transgenic mice carrying the SV40 T antigen oncogene under the transcriptional control of 773 base pairs of 5' flanking sequences from the rat TH gene. Although the lines continue to express T antigen, they exhibit neuronal properties such as neurofilaments and synaptophysin and lack glial intermediate filaments."

2. Source Organism Type

   Mus musculus

3. Developed by

   Chikaraishi, Dona

4. Location

   Beth A. Habecker Laboratory