Charles Roselli Laboratory

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1. Resource Description

   "My research goal is to obtain an integrated understanding of the steroid-sensitive brain circuitry, neurochemical mechanisms, and the subcellular signaling pathways that mediate the central actions of androgens. A major research focus is the characterization of the aromatase-signaling pathway in neural tissue. Aromatase is a cytochrome P450 enzyme (CYP 19) that catalyzes the conversion of testosterone to estradiol. Although androgens and brain-derived estrogens are believed to act coordinately to regulate brain function, the challenge is to understand the complexity of this interaction at a subcellular, cellular, and systems level. A second research direction in my laboratory aims to understand the cellular mechanism(s) by which herbal preparations inhibit prostate growth and to explore their potential as viable treatments for prostate carcinoma."

2. Contact

   Roselli, Charles, PhD

3. Website(s)

   http://www.ohsu.edu/xd/education/schools/school-of-medicine/departments/basic-science-departments/physpharm/faculty-staff/roselli.cfm

4. Secondary affiliation

   Department of Physiology & Pharmacology