Curcumin

eagle-i ID

Resource Type

Properties

1. Resource Description

   "A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope."

2. Additional Name

   (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

3. Additional Name

   Diferuloylmethane

4. Additional Name

   Diferulylmethane

5. Additional Name

   Natural Yellow 3

6. Manufacturer

   Sigma-Aldrich Co.

7. Related Publication or Documentation

   Curcumin blocks CCL2 induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity

8. Related Publication or Documentation

   Cellular adhesion assay protocol

9. CAS Number

   458-37-7

10. Website(s)

    http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=C1386|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC

11. Location

    Charles Roselli Laboratory