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Curcumin

eagle-i ID

http://ohsu.eagle-i.net/i/00000130-6ff6-daa4-0c8d-bb9080000000

Resource Type

  1. Organic small molecule

Properties

  1. Resource Description
    "A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope."
  2. Additional Name
    (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
  3. Additional Name
    Diferuloylmethane
  4. Additional Name
    Diferulylmethane
  5. Additional Name
    Natural Yellow 3
  6. Manufacturer
    Sigma-Aldrich Co.
  7. Related Publication or Documentation
    Curcumin blocks CCL2 induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity
  8. Related Publication or Documentation
    Cellular adhesion assay protocol
  9. CAS Number
    458-37-7
  10. Website(s)
    http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=C1386|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC
  11. Location
    Charles Roselli Laboratory
 
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016