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Ontology BAsed Molecular Signature
eagle-i ID
http://ohsu.eagle-i.net/i/0000013a-4196-47b7-b332-51b580000000
Resource Type
Properties
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Resource Description
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The ontologically based molecular signature (OBAMS) is a method to identify novel biomarkers and infers biological functions as characteristic of particular immune cell types. This method finds molecular signatures for cell types based on mapping biological samples to the Cell Ontology (CL) and navigating the space of all possible pairwise comparisons between cell types to find genes whose expression is core to a particular cell type’s identity. Expression data available from the Immunological Genome project (IGP) (www.immgen.org) was evaluated to identify unique biomarkers of mature B cell subtypes. The Gene Ontology was used to cluster cell types by shared biological processes in order to find candidate genes responsible for somatic hypermutation in germinal center B cells. This algorithm can be applied to other cell types as well.
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Additional Name
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OBAMS
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Used by
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Ontology Development Group
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Data Input
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Expression data available from the Immunological Genome project (IGP)
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Software purpose
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Gene expression analysis objective
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Related Publication or Documentation
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Ontology based molecular signatures for immune cell types via gene expression analysis.
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Website(s)
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http://www.cellontology.org/
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Website(s)
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http://www.immgen.org/
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Algorithm used
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Gene array analysis algorithm
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Coded in
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R language