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LSL-KrasG12D

http://ohsu.eagle-i.net/i/0000013b-4da2-8d56-c825-3bd680000000

Resource Description

LSL-KrasG12D carry a latent point-mutant allele of Kras2 (K-rasG12D). Cre-mediated recombination leads to deletion of a transcriptional termination sequence (Lox-Stop-Lox) and expression of the oncogenic protein.
Related Disease

cancer
Related Publication or Documentation

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
Website(s)

http://mouse.ncifcrf.gov/available_details.asp?ID=01XJ6
Parental Strain Name

B6.129
Genetic Alteration(s)

LSL-KrasG12D
Genetic Alteration(s)

PDX1-Cre
Location

Rosalie Sears Laboratory

Inferred Types from the eagle-i Ontology (What is an ontology?)

Provenance Metadata About This Resource Record