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RFS-MycT58A+/+/LSL-KrasG12D/P48-Cre

eagle-i ID

http://ohsu.eagle-i.net/i/0000013b-4df2-07a4-c825-3bd680000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    LSL-KrasG12D carry a latent point-mutant allele of Kras2 (K-rasG12D). Cre-mediated recombination leads to deletion of a transcriptional termination sequence (Lox-Stop-Lox) and expression of the oncogenic protein. P48-Cre is a pancreas-specific Cre recombinase transgene.
  2. Additional Name
    Rosa Floxed Stop-MycT58A+/+/LSL-KrasG12D/P48-Cre
  3. Related Disease
    pancreatic cancer
  4. Related Publication or Documentation
    Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
  5. Website(s)
    http://mouse.ncifcrf.gov/available_details.asp?ID=01XJ6
  6. Website(s)
    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&id=MGI:2387812
  7. Parental Strain Name
    B6.129
  8. Parental Strain Name
    C57BL/6
  9. Genetic Alteration(s)
    LSL-KrasG12D
  10. Genetic Alteration(s)
    RFS-MycT58A
  11. Genetic Alteration(s)
    P48-Cre
  12. Developed by
    Sears, Rosalie, Ph.D.
  13. Location
    Rosalie Sears Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record

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