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RFS-MycT58A+/+/LSL-KrasG12D/P48-Cre
eagle-i ID
http://ohsu.eagle-i.net/i/0000013b-4df2-07a4-c825-3bd680000000
Resource Type
Properties
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Resource Description
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LSL-KrasG12D carry a latent point-mutant allele of Kras2 (K-rasG12D). Cre-mediated recombination leads to deletion of a transcriptional termination sequence (Lox-Stop-Lox) and expression of the oncogenic protein.
P48-Cre is a pancreas-specific Cre recombinase transgene.
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Additional Name
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Rosa Floxed Stop-MycT58A+/+/LSL-KrasG12D/P48-Cre
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Related Disease
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pancreatic cancer
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Related Publication or Documentation
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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
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Website(s)
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http://mouse.ncifcrf.gov/available_details.asp?ID=01XJ6
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Website(s)
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http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&id=MGI:2387812
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Parental Strain Name
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B6.129
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Parental Strain Name
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C57BL/6
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Genetic Alteration(s)
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LSL-KrasG12D
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Genetic Alteration(s)
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RFS-MycT58A
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Genetic Alteration(s)
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P48-Cre
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Developed by
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Sears, Rosalie, Ph.D.
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Location
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Rosalie Sears Laboratory