RFS-MycWT+/+/LSL-KrasG12D

eagle-i ID

Resource Type

Properties

1. Resource Description

   LSL-KrasG12D carry a latent point-mutant allele of Kras2 (K-rasG12D). Cre-mediated recombination leads to deletion of a transcriptional termination sequence (Lox-Stop-Lox) and expression of the oncogenic protein.

2. Additional Name

   Rosa Floxed Stop-MycWT+/+/LSL-KrasG12D

3. Related Disease

   cancer

4. Related Publication or Documentation

   Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.

5. Website(s)

   http://mouse.ncifcrf.gov/available_details.asp?ID=01XJ6

6. Parental Strain Name

   B6.129

7. Parental Strain Name

   C57BL/6

8. Genetic Alteration(s)

   LSL-KrasG12D

9. Genetic Alteration(s)

   RFS-MycWT

10. Developed by

    Sears, Rosalie, Ph.D.

11. Location

    Rosalie Sears Laboratory