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B6.129(Cg)-Kcnn2<tm1.1Jpad>/J

eagle-i ID

http://ohsu.eagle-i.net/i/0000013b-9180-7605-c825-3bd680000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "SK2-delta mice harbor a null allele of the Kcnn2 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; also called SK2) gene, and may be useful in studying the role of small-conductance calcium-activated potassium (SK) channels in after-hyperpolarization and action potentials of neuronal, inner ear (cochlea), and urinary bladder tissues."
  2. Additional Name
    SK2-delete
  3. Inventory Number
    JAX Stock No. 009592
  4. Related Disease
    neurodegenerative disease
  5. Related Disease
    auditory system disease
  6. Related Disease
    bladder disease
  7. Related Publication or Documentation
    Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents.
  8. Related Publication or Documentation
    The SK2-long isoform directs synaptic localization and function of SK2-containing channels.
  9. Related Publication or Documentation
    T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites.
  10. Related Publication or Documentation
    SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons.
  11. Related Publication or Documentation
    Genetic deletion of SK2 channels in mouse inner hair cells prevents the developmental linearization in the Ca2+ dependence of exocytosis.
  12. Related Publication or Documentation
    Expression of the SK2 calcium-activated potassium channel is required for cholinergic function in mouse cochlear hair cells.
  13. Related Publication or Documentation
    Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation.
  14. Related Publication or Documentation
    SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells.
  15. Related Publication or Documentation
    Functional roles of a Ca2+-activated K+ channel in atrioventricular nodes.
  16. Related Publication or Documentation
    Kcnn2tm1.1Jpad genotyping protocol
  17. Website(s)
    http://jaxmice.jax.org/strain/009592.html
  18. Related Technique
    Electrophysiology assay
  19. Parental Strain Name
    C57BL/6J
  20. Biological process studied
    memory
  21. Genetic Alteration(s)
    Kcnn2[tm1.1Jpad]
  22. Developed by
    Adelman, John, PhD
  23. Phenotype Findings
    Abnormal action potential
  24. Phenotype Findings
    Abnormal afterhyperpolarization
  25. Location
    John Adelman laboratory
 
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