B6.129S4(Cg)-Kcnn2tm2Jpad/J

eagle-i ID

Resource Type

Properties

1. Resource Description

   "The SK2T mutant allele results in approximately ten-fold overexpression of the Kcnn2 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; also called SK2) gene product prior to administration of tetracycline (or its analog doxycycline (dox))."

2. Additional Name

   SK2-tTA

3. Inventory Number

   JAX Stock No. 009602

4. Related Disease

   neurodegenerative disease

5. Related Publication or Documentation

   Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents.

6. Related Publication or Documentation

   The SK2-long isoform directs synaptic localization and function of SK2-containing channels.

7. Related Publication or Documentation

   Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation.

8. Related Publication or Documentation

   Generic Cre Melt Curve Analysis

9. Related Publication or Documentation

   Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.

10. Related Publication or Documentation

    Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance.

11. Website(s)

    http://jaxmice.jax.org/strain/009602.html

12. Related Technique

    Electrophysiology assay

13. Parental Strain Name

    C57BL/6J

14. Biological process studied

    memory

15. Genetic Alteration(s)

    Kcnn2tm2Jpad

16. Developed by

    Adelman, John, PhD

17. Phenotype Findings

    Abnormal excitatory postsynaptic potential

18. Phenotype Findings

    Abnormal CNS synaptic transmission

19. Phenotype Findings

    Reduced long term potentiation

20. Phenotype Findings

    Abnormal contextual conditioning behavior (MGI Ref ID J:105645)

21. Phenotype Findings

    Abnormal spatial learning

22. Phenotype Findings

    Complete prenatal lethality

23. Location

    John Adelman laboratory