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B6.129S4(Cg)-Kcnn2tm2Jpad/J

eagle-i ID

http://ohsu.eagle-i.net/i/0000013b-9198-0a80-c825-3bd680000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "The SK2T mutant allele results in approximately ten-fold overexpression of the Kcnn2 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; also called SK2) gene product prior to administration of tetracycline (or its analog doxycycline (dox))."
  2. Additional Name
    SK2-tTA
  3. Inventory Number
    JAX Stock No. 009602
  4. Related Disease
    neurodegenerative disease
  5. Related Publication or Documentation
    Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents.
  6. Related Publication or Documentation
    The SK2-long isoform directs synaptic localization and function of SK2-containing channels.
  7. Related Publication or Documentation
    Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation.
  8. Related Publication or Documentation
    Generic Cre Melt Curve Analysis
  9. Related Publication or Documentation
    Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.
  10. Related Publication or Documentation
    Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance.
  11. Website(s)
    http://jaxmice.jax.org/strain/009602.html
  12. Related Technique
    Electrophysiology assay
  13. Parental Strain Name
    C57BL/6J
  14. Biological process studied
    memory
  15. Genetic Alteration(s)
    Kcnn2tm2Jpad
  16. Developed by
    Adelman, John, PhD
  17. Phenotype Findings
    Abnormal excitatory postsynaptic potential
  18. Phenotype Findings
    Abnormal CNS synaptic transmission
  19. Phenotype Findings
    Reduced long term potentiation
  20. Phenotype Findings
    Abnormal contextual conditioning behavior (MGI Ref ID J:105645)
  21. Phenotype Findings
    Abnormal spatial learning
  22. Phenotype Findings
    Complete prenatal lethality
  23. Location
    John Adelman laboratory
 
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