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B6.129S4-Kcnn3<tm1Jpad>/J

eagle-i ID

http://ohsu.eagle-i.net/i/0000013b-91c2-49b6-c825-3bd680000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "The SK3T mutant allele has a tetracycline-based genetic switch inserted into the 5' UTR of the Kcnn3 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; also called SK3) locus, just upstream of the translation initiation site. This genetic switch harbors both the tetracycline-controlled transactivator protein (tTA) as well as the tetracycline operator (tetO; also called tetracycline-responsive element (TRE) or tet-operator); allowing transcription of the downstream Kcnn3 locus to be blocked by administration of tetracycline (or its analog doxycycline (dox)). Homozygotes exhibit three-fold overexpression of SK3 before, and no SK3 expression during, doxycycline administration."
  2. Additional Name
    SK3-tTA
  3. Inventory Number
    JAX Stock No. 009603
  4. Related Disease
    cardiovascular system disease
  5. Related Disease
    neurodegenerative disease
  6. Related Disease
    myopathy
  7. Related Publication or Documentation
    Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents.
  8. Related Publication or Documentation
    Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation.
  9. Related Publication or Documentation
    Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance.
  10. Related Publication or Documentation
    Kcnn3tm1Jpad STD PCR genotyping protocol
  11. Related Publication or Documentation
    Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension.
  12. Related Publication or Documentation
    Myometrial expression of small conductance Ca2+-activated K+ channels depresses phasic uterine contraction.
  13. Related Publication or Documentation
    Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice.
  14. Related Publication or Documentation
    SK3 K+ channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors
  15. Related Publication or Documentation
    Crucial importance of the endothelial K+ channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contraction.
  16. Related Publication or Documentation
    Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses
  17. Related Publication or Documentation
    Altered expression of small-conductance Ca2+-activated K+ (SK3) channels modulates arterial tone and blood pressure
  18. Website(s)
    http://jaxmice.jax.org/strain/009603.html
  19. Related Technique
    Electrophysiology assay
  20. Parental Strain Name
    C57BL/6J
  21. Biological process studied
    Smooth muscle contraction
  22. Biological process studied
    memory
  23. Biological process studied
    Reproductive process
  24. Biological process studied
    Regulation of respiratory system process
  25. Genetic Alteration(s)
    Kcnn3tm1Jpad
  26. Developed by
    Adelman, John, PhD
  27. Phenotype Findings
    Pregnancy-related premature death
  28. Phenotype Findings
    Abnormal pulmonary respiratory rate
  29. Phenotype Findings
    Apnea
  30. Phenotype Findings
    *Normal* nervous system phenotype
  31. Location
    John Adelman laboratory
 
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