eagle-i Oregon Health & Science UniversityOregon Health & Science University
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eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    "These floxed-SK3 mutant mice possess loxP sites flanking the translation initiation codon, coding sequences of exon 1, and a portion of intron1 of the potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (Kcnn3) gene. SK3 is expressed in the soma and dendrites of dopaminergic neurons in the substantia nigra and influences their action potential frequency. Defects in dopamine (DA) releasing neurons have been sighted in pathologies such as schizophrenia and Parkinson's disease. SK3 is also expressed in smooth muscle of the bladder and uterus, and endothelia of the vasculature where the channels participate in blood pressure regulation. Mice that are homozygous for this allele are viable and fertile. When bred to mice that express tissue-specific Cre recombinase, resulting offspring will have exon 1 deleted in cre-expressing tissues."
  2. Additional Name
  3. Inventory Number
    JAX Stock No. 019083
  4. Related Disease
    neurodegenerative disease
  5. Related Publication or Documentation
    SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons.
  6. Related Publication or Documentation
    Kcnn3tm2.1Jpad, Standard PCR genotyping protocol
  7. Website(s)
  8. Related Technique
    Electrophysiology assay
  9. Parental Strain Name
  10. Biological process studied
    Smooth muscle contraction
  11. Biological process studied
  12. Genetic Alteration(s)
  13. Developed by
    Adelman, John, PhD
  14. Phenotype Findings
    Normal phenotype
  15. Location
    John Adelman laboratory
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016