B6.Cg-Kcnn3<tm2.1Jpad>/J

eagle-i ID

Resource Type

Properties

1. Resource Description

   "These floxed-SK3 mutant mice possess loxP sites flanking the translation initiation codon, coding sequences of exon 1, and a portion of intron1 of the potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (Kcnn3) gene. SK3 is expressed in the soma and dendrites of dopaminergic neurons in the substantia nigra and influences their action potential frequency. Defects in dopamine (DA) releasing neurons have been sighted in pathologies such as schizophrenia and Parkinson's disease. SK3 is also expressed in smooth muscle of the bladder and uterus, and endothelia of the vasculature where the channels participate in blood pressure regulation. Mice that are homozygous for this allele are viable and fertile. When bred to mice that express tissue-specific Cre recombinase, resulting offspring will have exon 1 deleted in cre-expressing tissues."

2. Additional Name

   SK3-flox

3. Inventory Number

   JAX Stock No. 019083

4. Related Disease

   neurodegenerative disease

5. Related Publication or Documentation

   SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons.

6. Related Publication or Documentation

   Kcnn3tm2.1Jpad, Standard PCR genotyping protocol

7. Website(s)

   http://jaxmice.jax.org/strain/019083.html

8. Related Technique

   Electrophysiology assay

9. Parental Strain Name

   C57BL/6J

10. Biological process studied

    Smooth muscle contraction

11. Biological process studied

    memory

12. Genetic Alteration(s)

    Kcnn3tm2.1Jpad

13. Developed by

    Adelman, John, PhD

14. Phenotype Findings

    Normal phenotype

15. Location

    John Adelman laboratory