DO11.10 TCR transgenic

eagle-i ID

Resource Type

Properties

1. Resource Description

   "Mice carrying the MHC class II restricted rearranged T cell receptor transgene, Tg(DO11.10)10Dlo, react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes within 20 hours of treatment indicates that apoptosis in important in the development of antigen-induced tolerance. Use of this rearranged T cell receptor transgene requires H2d background."

2. Related Disease

   immune system disease

3. Related Publication or Documentation

   APCs in the anterior uveal tract do not migrate to draining lymph nodes.

4. Website(s)

   http://jaxmice.jax.org/strain/003303.html

5. Parental Strain Name

   BALB/c

6. Genetic Alteration(s)

   Tg(DO11.10)10Dlo

7. Phenotype Findings

   Abnormal thymus physiology

8. Phenotype Findings

   Decreased CD4-positive T cell number

9. Phenotype Findings

   Decreased double-positive T cell number

10. Phenotype Findings

    Abnormal thymus physiology

11. Phenotype Findings

    Decreased CD4-positive T cell number

12. Phenotype Findings

    Decreased double-positive T cell number

13. Location

    Jim Rosenbaum laboratory