eagle-i Oregon Health & Science UniversityOregon Health & Science University
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DO11.10 TCR transgenic

eagle-i ID

http://ohsu.eagle-i.net/i/0000013b-91fd-f9b9-c825-3bd680000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "Mice carrying the MHC class II restricted rearranged T cell receptor transgene, Tg(DO11.10)10Dlo, react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes within 20 hours of treatment indicates that apoptosis in important in the development of antigen-induced tolerance. Use of this rearranged T cell receptor transgene requires H2d background."
  2. Related Disease
    immune system disease
  3. Related Publication or Documentation
    APCs in the anterior uveal tract do not migrate to draining lymph nodes.
  4. Website(s)
    http://jaxmice.jax.org/strain/003303.html
  5. Parental Strain Name
    BALB/c
  6. Genetic Alteration(s)
    Tg(DO11.10)10Dlo
  7. Phenotype Findings
    Abnormal thymus physiology
  8. Phenotype Findings
    Decreased CD4-positive T cell number
  9. Phenotype Findings
    Decreased double-positive T cell number
  10. Phenotype Findings
    Abnormal thymus physiology
  11. Phenotype Findings
    Decreased CD4-positive T cell number
  12. Phenotype Findings
    Decreased double-positive T cell number
  13. Location
    Jim Rosenbaum laboratory
 
RDFRDF
 
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016