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M. Tuberculosis H37Rv

eagle-i ID


Resource Type

  1. Mycobacterium tuberculosis


  1. Resource Description
    The Lewinsohn laboratory is focused on understanding the mechanisms by which human CD8+ T cells recognize cell infected with Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis. Areas of interest within the laboratory include: 1) Defining the repertoire of immunodominant antigens in Mtb. Here, we have focused on antigens that are presented by classical HLA molecules (HLA-A, B, and C) as well as those presented by non-classical molecules such has HLA-E. 2) Defining the mechanisms by which Mtb-antigens can enter the HLA-I antigen processing pathway. Because Mtb is an organisms normally found within the phagosome (traditionally a HLA-II processing compartment). We are currently focused on the role of the phagosome as a HLA-I processing compartment. 3) Defining the mechanisms by which innate T cells can recognize those cells infected with Mtb. Here, early recognition of these cells might directly limit intracellular replication of Mtb, or might promote the development of an effective adaptive immune response.
  2. Related Disease
  3. Related Publication or Documentation
    Secreted immunodominant Mycobacterium tuberculosis antigens are processed by the cytosolic pathway.
  4. Related Publication or Documentation
    Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress.
  5. Related Publication or Documentation
    Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells
  6. Related Publication or Documentation
    The Mycobacterium tuberculosis Phagosome Is a HLA-I Processing Competent Organelle
  7. Related Technique
    Liquid chromatography-mass spectrometry
  8. Related Technique
    Intracellular cytokine staining assay
  9. Related Technique
    ELISPOT assay
  10. Biological process studied
    Immune response
  11. Location
    David Lewinsohn laboratory
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016