M. Tuberculosis H37Ra

eagle-i ID

Resource Type

Properties

1. Resource Description

   The Lewinsohn laboratory is focused on understanding the mechanisms by which human CD8+ T cells recognize cell infected with Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis. Areas of interest within the laboratory include: 1) Defining the repertoire of immunodominant antigens in Mtb. Here, we have focused on antigens that are presented by classical HLA molecules (HLA-A, B, and C) as well as those presented by non-classical molecules such has HLA-E. 2) Defining the mechanisms by which Mtb-antigens can enter the HLA-I antigen processing pathway. Because Mtb is an organisms normally found within the phagosome (traditionally a HLA-II processing compartment). We are currently focused on the role of the phagosome as a HLA-I processing compartment. 3) Defining the mechanisms by which innate T cells can recognize those cells infected with Mtb. Here, early recognition of these cells might directly limit intracellular replication of Mtb, or might promote the development of an effective adaptive immune response.

2. Related Disease

   tuberculosis

3. Related Publication or Documentation

   Secreted immunodominant Mycobacterium tuberculosis antigens are processed by the cytosolic pathway.

4. Related Publication or Documentation

   Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

5. Related Technique

   Liquid chromatography-mass spectrometry

6. Related Technique

   Intracellular cytokine staining assay

7. Related Technique

   ELISPOT assay

8. Biological process studied

   Immune response

9. Location

   David Lewinsohn laboratory