Mycobacterium tuberculosis
M. Tuberculosis H37Ra
The Lewinsohn laboratory is focused on understanding the mechanisms by which human CD8+ T cells recognize cell infected with Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis. Areas of interest within the laboratory include:
1) Defining the repertoire of immunodominant antigens in Mtb. Here, we have focused on antigens that are presented by classical HLA molecules (HLA-A, B, and C) as well as those presented by non-classical molecules such has HLA-E.
2) Defining the mechanisms by which Mtb-antigens can enter the HLA-I antigen processing pathway. Because Mtb is an organisms normally found within the phagosome (traditionally a HLA-II processing compartment). We are currently focused on the role of the phagosome as a HLA-I processing compartment.
3) Defining the mechanisms by which innate T cells can recognize those cells infected with Mtb. Here, early recognition of these cells might directly limit intracellular replication of Mtb, or might promote the development of an effective adaptive immune response.
Resource Description
resource_description
Related Publication or Documentation
has documentation
has_documentation
Secreted immunodominant Mycobacterium tuberculosis antigens are processed by the cytosolic pathway.
Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells
Related Disease
model of
model_of
tuberculosis
Related Technique
Intracellular cytokine staining assay
related technique
intracellular cytokine staining assay
related_technique
intracellular cytokine staining assay
ELISPOT assay
ELISPOT assay
Liquid chromatography-mass spectrometry
liquid chromatography-mass spectrometry
Biological process studied
Immune response
used to study
used_to_study
immune response
Location
located_in
David Lewinsohn laboratory
located in
2013-01-22T12:48:38.444-06:00
nvasilevsky (Nicole Vasilevsky)
2013-03-18T23:55:31.124-05:00
workflow state
Published
nvasilevsky (Nicole Vasilevsky)
Organism or Virus
organism
organism
Organism
non viral organism
Prokaryota
Prokaryota
Bacteria
Actinobacteria <phylum>
material_entity
independent_continuant
continuant
entity