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D4-receptor KO
eagle-i ID
http://ohsu.eagle-i.net/i/0000013c-84d9-e7d1-c825-3bd680000000
Resource Type
Mus musculus
Properties
Additional Name
D(4)KO
Additional Name
D4-receptor Knockout
Related Disease
attention deficit hyperactivity disorder
Related Disease
alcohol abuse
Related Disease
substance-related disorder
Related Disease
cocaine abuse
Related Publication or Documentation
D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking.
Related Publication or Documentation
Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine.
Related Technique
Behavioral assay
Parental Strain Name
C57Bl/6J × 129/Ola F1
Genetic Alteration(s)
D4-receptor KO
Developed by
Grandy, David
Phenotype Findings
Heightened impulsivity and novelty seeking
Location
Suzanne Mitchell Laboratory
Inferred Types from the eagle-i Ontology (
What is an ontology?
)
entity
continuant
independent_continuant
material_entity
Organism
Mus <mouse, genus>
Glires
Mammalia
Chordata
Vertebrata <Metazoa>
Rodentia
Organism or Virus
Thing
Provenance Metadata About This Resource Record
workflow state
Published
contributor
nvasilevsky (Nicole Vasilevsky)
created
2013-01-28T23:49:06.788-06:00
creator
nvasilevsky (Nicole Vasilevsky)
modified
2013-03-19T23:03:36.737-05:00