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129P3/J
eagle-i ID
http://ohsu.eagle-i.net/i/0000013c-8e65-7698-c825-3bd680000000
Resource Type
Properties
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Exchange facilitator
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<a href=http://jaxmice.jax.org/strain/000690.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>
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Resource Description
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"Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. (1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently, 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T). Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line."
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Inventory Number
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Jax Stock No. 000690
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Related Disease
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alcohol abuse
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Related Disease
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substance-related disorder
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Related Publication or Documentation
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Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains.
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Parental Strain Name
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129P
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Phenotype Findings
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Age related hearing loss
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Location
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Suzanne Mitchell Laboratory