eagle-i Oregon Health & Science UniversityOregon Health & Science University
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AKR/J

eagle-i ID

http://ohsu.eagle-i.net/i/0000013c-8e66-13e5-c825-3bd680000000

Resource Type

  1. Mus musculus

Properties

  1. Exchange facilitator
    <a href=http://jaxmice.jax.org/strain/000648.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>
  2. Resource Description
    "Originally inbred at the Rockefeller Institute, AKR mice are widely used in cancer research for their high leukemia incidence (60-90%) and in immunology as a source of the Thy1.1 (theta AKR) antigen. AKR/J mice are viremic from birth, and express the ecotropic retrovirus AKV in all tissues. The hair interior defect (hid) mutation, a strain characteristic of AKR mice, causes alterations in hair development that is only evident microscopically. Adrenocortical lipid depletion (ald) in AKR mice is caused by a mutation in sterol O-acyltransferase 1 (Soat1), and leads to a truncated SOAT1 protein. AKR/J mice are relatively resistant to aortic lesion formation on a semi-synthetic high fat diet and are hyporesponsive to diets containing high levels of fat and cholesterol."
  3. Additional Name
    Soat1
  4. Inventory Number
    Jax Stock Number: 000648
  5. Related Disease
    alcohol abuse
  6. Related Disease
    substance-related disorder
  7. Related Publication or Documentation
    Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains.
  8. Parental Strain Name
    Multiple strains
  9. Phenotype Findings
    Albino
  10. Location
    Suzanne Mitchell Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record

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