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AKR/J
eagle-i ID
http://ohsu.eagle-i.net/i/0000013c-8e66-13e5-c825-3bd680000000
Resource Type
Properties
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Exchange facilitator
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<a href=http://jaxmice.jax.org/strain/000648.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>
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Resource Description
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"Originally inbred at the Rockefeller Institute, AKR mice are widely used in cancer research for their high leukemia incidence (60-90%) and in immunology as a source of the Thy1.1 (theta AKR) antigen. AKR/J mice are viremic from birth, and express the ecotropic retrovirus AKV in all tissues. The hair interior defect (hid) mutation, a strain characteristic of AKR mice, causes alterations in hair development that is only evident microscopically. Adrenocortical lipid depletion (ald) in AKR mice is caused by a mutation in sterol O-acyltransferase 1 (Soat1), and leads to a truncated SOAT1 protein. AKR/J mice are relatively resistant to aortic lesion formation on a semi-synthetic high fat diet and are hyporesponsive to diets containing high levels of fat and cholesterol."
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Additional Name
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Soat1
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Inventory Number
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Jax Stock Number: 000648
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Related Disease
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alcohol abuse
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Related Disease
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substance-related disorder
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Related Publication or Documentation
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Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains.
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Parental Strain Name
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Multiple strains
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Phenotype Findings
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Albino
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Location
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Suzanne Mitchell Laboratory