Mus musculus
AKR/J
"Originally inbred at the Rockefeller Institute, AKR mice are widely used in cancer research for their high leukemia incidence (60-90%) and in immunology as a source of the Thy1.1 (theta AKR) antigen. AKR/J mice are viremic from birth, and express the ecotropic retrovirus AKV in all tissues. The hair interior defect (hid) mutation, a strain characteristic of AKR mice, causes alterations in hair development that is only evident microscopically. Adrenocortical lipid depletion (ald) in AKR mice is caused by a mutation in sterol O-acyltransferase 1 (Soat1), and leads to a truncated SOAT1 protein. AKR/J mice are relatively resistant to aortic lesion formation on a semi-synthetic high fat diet and are hyporesponsive to diets containing high levels of fat and cholesterol."
Resource Description
resource_description
Soat1
Additional Name
eagle-i_synonym
Related Publication or Documentation
has documentation
has_documentation
Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains.
Related Disease
model of
model_of
substance-related disorder
alcohol abuse
Jax Stock Number: 000648
Inventory Number
has inventory number
has_inventory_number
Multiple strains
Parental Strain Name
has parental strain name
has_parental_strain_name
Phenotype Findings
Mammal-specific phenotype
has_phenotype_annotation
Albino
mammalian phenotype annotation
Albino
absent coat pigmentation
absent eye pigmentation
information content entity
information content entity
Phenotype
phenotypic annotation
conclusion textual entity
conclusion textual entity
continuant
entity
generically dependent continuant
<a href=http://jaxmice.jax.org/strain/000648.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>
Exchange facilitator
has exchange facilitator
has_exchange_facilitator
Location
located_in
Suzanne Mitchell Laboratory
located in
2013-01-30T20:18:48.690-06:00
nvasilevsky (Nicole Vasilevsky)
2015-11-20T13:56:22.033-06:00
workflow state
Published
tjohnson (Tenille Johnson)
Organism or Virus
organism
organism
Mus <mouse, genus>
Mammalia
Rodentia
Organism
non viral organism
Chordata
Vertebrata <Metazoa>
Glires
material_entity
independent_continuant
continuant
entity