C57BL/6J

eagle-i ID

Resource Type

Properties

1. Exchange facilitator

   <a href=http://jaxmice.jax.org/strain/000664.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>

2. Resource Description

   "C57BL/6 is the most widely used inbred strain. It is commonly used as a general purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice. Overall, C57BL/6 mice breed well, are long-lived, and have a low susceptibility to tumors. Primitive hematopoietic stem cells from C57BL/6J mice show greatly delayed senescence relative to BALB/c and DBA/2J. This is a dominant trait. Other characteristics include: 1) a high susceptibility to diet-induced obesity, type 2 diabetes, and atherosclerosis; 2) a high incidence of microphthalmia and other associated eye abnormalities; 3) resistance to audiogenic seizures; 4) low bone density; 5) hereditary hydrocephalus (early reports indicate 1 - 4 %); 6) hairloss associated with overgrooming, 7) a preference for alcohol and morphine; 8) late-onset hearing loss; and 9) increased incidence of hydrocephalus and malocclusion."

3. Additional Name

   B6

4. Additional Name

   B6J

5. Additional Name

   Black 6

6. Additional Name

   C57 Black

7. Related Disease

   alcohol abuse

8. Related Publication or Documentation

   Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains.

9. Related Technique

   Behavioral assay

10. Location

    Suzanne Mitchell Laboratory