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C57L/J

eagle-i ID

http://ohsu.eagle-i.net/i/0000013c-8e66-9245-c825-3bd680000000

Resource Type

  1. Mus musculus

Properties

  1. Exchange facilitator
    <a href=http://jaxmice.jax.org/strain/000668.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>
  2. Resource Description
    "C57L/J mice are used widely in research as a general purpose strain. Mice have a high incidence of Hodgkin's-like reticulum cell neoplasm at 18 months of age and pituitary tumors in old multiparous females. C57L/J mice are highly susceptible to experimental allergic encephalomyelitis (EAE) and highly responsive to phytohemagglutinin. In addition, C57L/J mice are highly susceptible to developing atherosclerotic aortic lesions (4500 to 8000 um2 atherosclerotic aortic lesions/aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat) (Paigen et al. 1990). On a lithogenic diet, C57L/J mice develop gallstones as a result of abnormal regulation of cholesterol synthesis (Xua et al. 2004). C57L/J mice carry no detectable endogenous ecotropic MuLV DNA sequences."
  3. Inventory Number
    Jax Stock Number: 000668
  4. Related Disease
    alcohol abuse
  5. Related Publication or Documentation
    Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains.
  6. Related Technique
    Behavioral assay
  7. Parental Strain Name
    C57BL/6J
  8. Location
    Suzanne Mitchell Laboratory
 
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