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C58/J

eagle-i ID

http://ohsu.eagle-i.net/i/0000013c-8e66-a70b-c825-3bd680000000

Resource Type

  1. Mus musculus

Properties

  1. Exchange facilitator
    <a href=http://jaxmice.jax.org/strain/000669.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>
  2. Resource Description
    "This strain was developed by MacDowell in 1921 from litter mates 58 and 52 of Miss Lathrop's stock. A mating of the same male but a different female gave rise to the commonly used C57BL group of strains. C58/J mice exhibit a high incidence of leukemia (>90% by one year of age). C58/J mice also exhibit an intermediate susceptibility to developing atherosclerotic aortic lesions (1670 to 1690 um2 atherosclerotic aortic lesions/aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat). Bone marrow cells of C58/J mice (and mice of 9 other strains, excluding closely derived C57 strains) carry the interleukin 3 receptor, alpha chain; mutation 1 allele (Il3ram1) which confers non-responsiveness to Interleukin-3 (IL-3). IL-3 normally stimulates colony formation of multiple lineages of hematopoietic cells. Other characteristics include: low social preference, poor performance in the T-maze, and overt motoric stereotypy. C58/J mice are homozygous for the high affinity aryl-hydrocarbon receptor; b-1 variant (Ahrb-1)."
  3. Inventory Number
    Jax Stock Number: 000669
  4. Related Disease
    alcohol abuse
  5. Related Publication or Documentation
    Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains.
  6. Related Technique
    Behavioral assay
  7. Parental Strain Name
    C57BL/6J
  8. Location
    Suzanne Mitchell Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record

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