Mus musculus
DBA/1J
"DBA/1J mice are widely used as a model for rheumatoid arthritis: immunization with type II collagen leads to the development of severe polyarthritis mediated by an autoimmune response. The incidence of collagen induced arthritis varies by experimental protocol, but is less than 100%. Similar to the human condition, mice with collagen-induced arthritis display synovitis and erosions of cartilage and bone. In addition, susceptibility in both humans and mice is linked to the expression of specific MHC class II molecules. DBA/1J mice show an intermediate susceptibility to developing atherosclerotic aortic lesions on an atherogenic diet. In response to challenge, DBA/1J mice develop immune-mediated nephritis characterized by proteinuria, glomerulonephritis and tubulointerstitial disease (Xie et al., 2004). There is high incidence of calcified lesions of the tongue with age. This strain is among the least responsive to phytohemagglutinin (Heiniger et al., 1975)."
Resource Description
resource_description
Related Publication or Documentation
has documentation
has_documentation
Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains.
Related Disease
model of
model_of
alcohol abuse
Jax Stock Number: 000670
Inventory Number
has inventory number
has_inventory_number
Related Technique
Behavioral assay
related technique
related_technique
behavioral assay
Multiple strains
Parental Strain Name
has parental strain name
has_parental_strain_name
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Exchange facilitator
has exchange facilitator
has_exchange_facilitator
Location
located_in
Suzanne Mitchell Laboratory
located in
2013-01-30T20:19:34.561-06:00
nvasilevsky (Nicole Vasilevsky)
2015-11-20T14:06:52.195-06:00
workflow state
Published
tjohnson (Tenille Johnson)
Organism or Virus
organism
organism
Mus <mouse, genus>
Mammalia
Rodentia
Organism
non viral organism
Chordata
Vertebrata <Metazoa>
Glires
material_entity
independent_continuant
continuant
entity