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DBA/2J

eagle-i ID

http://ohsu.eagle-i.net/i/0000013c-8e66-f0c8-c825-3bd680000000

Resource Type

  1. Mus musculus

Properties

  1. Exchange facilitator
    <a href=http://jaxmice.jax.org/strain/000671.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>
  2. Resource Description
    "DBA/2J is a widely used inbred strain that is valuable in a large number of research areas, including cardiovascular biology, neurobiology, and sensorineural research. Its characteristics are often contrasted with those of the C57BL/6J inbred strain (Stock No. 000664). DBA/2J mice show a low susceptibility to developing atherosclerotic aortic lesions (20 to 350 um2 atherosclerotic aortic lesions /aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat). They also exhibit high-frequency hearing loss beginning roughly at the time of weaning/adolescence (between three to four weeks of age) and becoming severe by two to three months of age. The age related hearing loss 8 mutation arose spontaneously in DBA/2J between 1951 and 1975. This strain possesses three recessive alleles that cause progressive cochlear pathology initially affecting the organ of Corti. Decreasing anteroventral cochlear nucleus volume decreases and neuron loss parallel the progression of peripheral hearing loss. Young DBA/2J inbred mice are also susceptible to audiogenic seizures due to the asp2 mutation, however, this susceptibility decreases as animals reach adulthood. There is high incidence of calcareous pericarditis, and calcified lesions of the testes, tongue and skeletal muscle. This strain is among the least responsive to phytohemagglutinin (Heiniger et al., 1975)."
  3. Inventory Number
    Jax Stock Number: 000671
  4. Related Disease
    alcohol abuse
  5. Related Publication or Documentation
    Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains.
  6. Parental Strain Name
    Multiple strains
  7. Location
    Suzanne Mitchell Laboratory
 
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