NZB/B1NJ

eagle-i ID

Resource Type

Properties

1. Exchange facilitator

   <a href=http://jaxmice.jax.org/strain/000684.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>

2. Resource Description

   "NZB/BlNJ mice display a number of autoimmune abnormalities including hemolytic anemia, elevated levels of immunoglobulin, anti-DNA antibodies, anti-thymocyte antibodies, and circulating immune complexes causing glomerulonephritis. F1 hybrids of NZB/BlNJ and NZW/LacJ (NZBWF1/J, Stock No. 100008) are widely used as a model for autoimmune disease resembling human systemic lupus erythematosus. NZB/BlNJ mice, fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat), fail to develop atherosclerotic aortic lesions in contrast to several highly susceptible strains of mice (e.g. C57BL/6J, Stock No. 000664; C57L/J, Stock No. 000668, C57BR/cdJ, Stock No. 000667, and SM/J, Stock No. 000687)."

3. Inventory Number

   Jax Stock Number: 000684

4. Related Disease

   alcohol abuse

5. Related Publication or Documentation

   Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains.

6. Related Technique

   Behavioral assay

7. Parental Strain Name

   Multiple strains

8. Location

   Suzanne Mitchell Laboratory