SWR/J

eagle-i ID

Resource Type

Properties

1. Exchange facilitator

   <a href=http://jaxmice.jax.org/strain/000689.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>

2. Resource Description

   "SWR/J mice are used widely in research as a general purpose strain. Aging mice exhibit a high incidence of lung and mammary gland tumors. They also develop extreme polydipsia and polyuria (nephrogenic diabetes insipidus) with increasing age. SWR/J mice are highly susceptible to experimental allergic encephalomyelitis (EAE). Germline deletion of about 50% of T-cell receptor V beta-chain gene segments and a T-cell receptor V alpha polymorphism are responsible for the resistance of SWR/J mice to collagen type II-induced arthritis. SWR/J mice show an intermediate susceptibility to developing atherosclerotic aortic lesions (1670 to 1690 um2 atherosclerotic aortic lesions/aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat). SWR/J mice have been recommended for generation and propogation of transgenic mice because they are high responders to exogenous hormones, have large and prominant pronuclei with good resistance to lysis following microinjection, and are genetically well-defined. SWR/J mice may also be used as controls for comparison to the autoimmune diabetic NOD/ShiLtJ mice (Stock No. 001976), especially for experiments examining the aberrant immune functions of NOD/ShiLtJ mice. Both NOD and SWR/J mice are derived from Swiss mice. SWR/J are in some cases more suitable than random bred Swiss ICR mice because of their genetic uniformity. Unlike NOD/ShiLtJ mice they are not immunocompromised, and they are genetically very different from NOD. SWR/J mice appear to be the only inbred carrying the allele Soaa (Taster) characterized by avoidance of sucrose octaacetate solutions at low concentrations (< 10-3M)."

3. Inventory Number

   Jax Stock Number: 000689

4. Related Disease

   alcohol abuse

5. Related Disease

   amphetamine abuse

6. Related Publication or Documentation

   Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains.

7. Related Technique

   Behavioral assay

8. Phenotype Findings

   Albino

9. Location

   Suzanne Mitchell Laboratory