KI Fgfr3KO / TG Col2-pd2GFP

eagle-i ID

Resource Type

Properties

1. Resource Description

   This strain is homozygous for the Col2-pd2GFP transgene and heterozygous for the Fgfr3 knockout allele.

2. Related Disease

   bone disease

3. Related Disease

   cartilage disease

4. Genetic Alteration(s)

   Fgfr3 knockout

5. Genetic Alteration(s)

   Col2-pd2GFP transgene

6. Phenotype Findings

   KO heterozygotes show some skeletal overgrowth, but are essentially normal.

7. Phenotype Findings

   The GFP transgene does not affect the phenotype.

8. Phenotype Findings

   KO homozygotes exhibit an elongated skeletal eventually developing scoliosis and kiphosis.

9. Location

   Bill Horton Laboratory