Mus musculus
KI Fgfr3TDII / TG Col2-pd2GFP
Insertion of 2 transgenes consisting of knock-in of activating mutation found in thanatophoric dysplasia into Fgfr3 locus and the Col2 promoter driving GFP.
Resource Description
resource_description
Related Disease
model of
model_of
cartilage disease
Genetic Alteration(s)
has sequence alteration
has_sequence_alteration
Col2-pd2GFP transgene
KI Fgfr3TDII
Phenotype Findings
Mammal-specific phenotype
has_phenotype_annotation
Dwarf phenotype
mammalian phenotype annotation
Dwarf phenotype
Knock-in Fgfr3 TDII produces a dwarf phenotype, mild in heterozygotes and severe in homozygotes, and chondrocytes express GFP.
Skeletal system
skeletal system
proportional dwarf
peramorphic growth
information content entity
information content entity
Phenotype
phenotypic annotation
conclusion textual entity
conclusion textual entity
continuant
entity
generically dependent continuant
Location
located_in
Bill Horton Laboratory
located in
2013-02-04T15:31:51.258-06:00
nvasilevsky (Nicole Vasilevsky)
2013-02-04T15:34:17.671-06:00
workflow state
Published
nvasilevsky (Nicole Vasilevsky)
Organism or Virus
organism
organism
Mus <mouse, genus>
Mammalia
Rodentia
Organism
non viral organism
Chordata
Vertebrata <Metazoa>
Glires
material_entity
independent_continuant
continuant
entity