Amanda Vinson Laboratory

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1. Resource Description

   "The Vinson Lab is focused on developing large genotyped and phenotyped pedigrees of rhesus macaques in order to study the genetic basis of complex diseases that severely impact the health of both macaques and humans. These diseases include cardiovascular disease and obesity in humans, and endometriosis and colitis in macaques, among others. To characterize the genetic basis of these diseases, they apply quantitative genetic approaches to estimate the heritability of risk factors for disease, to locate quantitative trait loci (QTLs) that influence these risk factors, and to identify functional genetic variants at identified QTLs. They have a particular interest in genetic effects on chronic inflammation and how these effects contribute to increased cardiovascular risk. Based on a subset of >750 macaques sampled to date, they have recently demonstrated significant heritability for total cholesterol, LDL cholesterol, triglycerides, abdominal circumference, and BMI in a single extended pedigree containing ~1,300 animals spanning 6 generations. Currently, they are working to develop genome-wide genetic data in these pedigreed macaques that will enable a search for QTLs that influence these cardiovascular risk factors, as well as risk factors for other important diseases."

2. PI

   Vinson, Amanda, Ph.D.

3. Affiliation

   Oregon National Primate Research Center

4. Website(s)

   http://www.ohsu.edu/xd/research/centers-institutes/onprc/scientific-discovery/scientists/amanda-vinson.cfm?WT_rank=1

5. Secondary affiliation

   Department of Molecular & Medical Genetics, Oregon Health & Science University