YetCre13

eagle-i ID

Resource Type

Properties

1. Exchange facilitator

   <a href=http://jaxmice.jax.org/strain/017353.html target=_window><img src=http://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>

2. Resource Description

   "The YetCre-13 allele has a bicistronic IRES-YFP-Cre reporter/recombinase cassette inserted between the translational stop codon and the 3' UTR of the interleukin 13 (Il13) gene; thus expressing the endogenous gene and the YFP-Cre fusion protein (yellow fluorescent protein/humanized [mammalian codon-optimized] Cre recombinase). These YetCre-13 mice may be useful for fluorescent reporter and/or Cre-lox studies of IL-13-expressing cells in type 2 immunity/host response to allergens and parasitic helminths. They may also be useful to track lineage-negative innate type 2 helper cells (Ih2 cells) that arise during type 2 immunity or in response to IL-25 and IL-33."

3. Additional Name

   C.129S4(B6)-Il13<tm1(YFP/cre)Lky/J>

4. Inventory Number

   Jax Stock Number: 017353

5. Related Disease

   cancer

6. Parental Strain Name

   129S4/SvJae-Tg(Prm-cre)70Og

7. Genetic Alteration(s)

   Il13<tm1(YFP/cre)Lky>

8. Location

   Lisa Coussens Laboratory