eagle-i Oregon Health & Science UniversityOregon Health & Science University
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eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    "Pdx-1-Cre mice exhibit a stochastic pattern of high-level Cre expression in the pancreas (Hingorani et al., 2003). When combined with Tyler Jacks' latent activatable K-ras allele, LSL-KrasG12D (Kras2, NCI Mouse Repository strain code 01XJ6), Pdx-1-Cre causes ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs). Some of these lesions progress to invasive and metastatic adenocarcinomas."
  2. Additional Name
  3. Inventory Number
    Strain #: 01XL5
  4. Related Disease
    pancreatic cancer
  5. Website(s)
  6. Parental Strain Name
  7. Genetic Alteration(s)
    Cre recombinase
  8. Genetic Alteration(s)
    Insulin promoter factor 1 (Ipf1, Pdx1)
  9. Developed by
    Lowy, Andrew M.
  10. Location
    Lisa Coussens Laboratory
Provenance Metadata About This Resource Record
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016