B6.FVB-Tg(Ipf1-cre)1Tuv

eagle-i ID

Resource Type

Properties

1. Resource Description

   "Pdx-1-Cre mice exhibit a stochastic pattern of high-level Cre expression in the pancreas (Hingorani et al., 2003). When combined with Tyler Jacks' latent activatable K-ras allele, LSL-KrasG12D (Kras2, NCI Mouse Repository strain code 01XJ6), Pdx-1-Cre causes ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs). Some of these lesions progress to invasive and metastatic adenocarcinomas."

2. Additional Name

   Pdx-1-cre

3. Inventory Number

   Strain #: 01XL5

4. Related Disease

   pancreatic cancer

5. Website(s)

   http://mouse.ncifcrf.gov/available_details.asp?ID=01XL5

6. Parental Strain Name

   B6.FVB

7. Genetic Alteration(s)

   Cre recombinase

8. Genetic Alteration(s)

   Insulin promoter factor 1 (Ipf1, Pdx1)

9. Developed by

   Lowy, Andrew M.

10. Location

    Lisa Coussens Laboratory