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B6.FVB-Tg(Ipf1-cre)1Tuv

eagle-i ID

http://ohsu.eagle-i.net/i/0000013d-f07e-7e75-f60f-bfff80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "Pdx-1-Cre mice exhibit a stochastic pattern of high-level Cre expression in the pancreas (Hingorani et al., 2003). When combined with Tyler Jacks' latent activatable K-ras allele, LSL-KrasG12D (Kras2, NCI Mouse Repository strain code 01XJ6), Pdx-1-Cre causes ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs). Some of these lesions progress to invasive and metastatic adenocarcinomas."
  2. Additional Name
    Pdx-1-cre
  3. Inventory Number
    Strain #: 01XL5
  4. Related Disease
    pancreatic cancer
  5. Website(s)
    http://mouse.ncifcrf.gov/available_details.asp?ID=01XL5
  6. Parental Strain Name
    B6.FVB
  7. Genetic Alteration(s)
    Cre recombinase
  8. Genetic Alteration(s)
    Insulin promoter factor 1 (Ipf1, Pdx1)
  9. Developed by
    Lowy, Andrew M.
  10. Location
    Lisa Coussens Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record

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