See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.
B6.129S4-Krastm4Tyj/J
eagle-i ID
http://ohsu.eagle-i.net/i/0000013d-f07f-5d0c-f60f-bfff80000000
Resource Type
Properties
-
-
Resource Description
-
"This strain carries a point mutation (G12D) in the Kras (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) gene whose expression is blocked by the presence of a loxP-flanked stop codon. Homozygotes die in utero. Cre-mediated recombination can excise the stop codon and permit the oncogenic protein to be expressed. Intranasal infection with an adenovirus encoding Cre results in a very high frequency of lung tumors and permits controlled timing of tumor initiation and tumor multiplicity. This strain may be useful in studies of cancer and development."
-
-
Inventory Number
-
Jax Stock Number: 008179
-
-
Related Disease
-
pancreatic cancer
-
-
Website(s)
-
http://jaxmice.jax.org/strain/008179.html
-
-
Website(s)
-
http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2429948
-
-
Parental Strain Name
-
129S4/SvJae
-
-
Genetic Alteration(s)
-
Kras[tm4Tyj]
-
-
Developed by
-
Jacks, Tyler
-
-
Location
-
Lisa Coussens Laboratory