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B6.129S4-Krastm4Tyj/J

eagle-i ID

http://ohsu.eagle-i.net/i/0000013d-f07f-5d0c-f60f-bfff80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "This strain carries a point mutation (G12D) in the Kras (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) gene whose expression is blocked by the presence of a loxP-flanked stop codon. Homozygotes die in utero. Cre-mediated recombination can excise the stop codon and permit the oncogenic protein to be expressed. Intranasal infection with an adenovirus encoding Cre results in a very high frequency of lung tumors and permits controlled timing of tumor initiation and tumor multiplicity. This strain may be useful in studies of cancer and development."
  2. Inventory Number
    Jax Stock Number: 008179
  3. Related Disease
    pancreatic cancer
  4. Website(s)
    http://jaxmice.jax.org/strain/008179.html
  5. Website(s)
    http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2429948
  6. Parental Strain Name
    129S4/SvJae
  7. Genetic Alteration(s)
    Kras[tm4Tyj]
  8. Developed by
    Jacks, Tyler
  9. Location
    Lisa Coussens Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016