Mus musculus
B6.129S4-Krastm4Tyj/J
http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2429948
Website(s)
has URL
has_url
http://jaxmice.jax.org/strain/008179.html
"This strain carries a point mutation (G12D) in the Kras (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) gene whose expression is blocked by the presence of a loxP-flanked stop codon. Homozygotes die in utero. Cre-mediated recombination can excise the stop codon and permit the oncogenic protein to be expressed. Intranasal infection with an adenovirus encoding Cre results in a very high frequency of lung tumors and permits controlled timing of tumor initiation and tumor multiplicity. This strain may be useful in studies of cancer and development."
Resource Description
resource_description
Related Disease
model of
model_of
pancreatic cancer
Jax Stock Number: 008179
Inventory Number
has inventory number
has_inventory_number
Genetic Alteration(s)
has sequence alteration
has_sequence_alteration
Kras[tm4Tyj]
129S4/SvJae
Parental Strain Name
has parental strain name
has_parental_strain_name
Developed by
resource_developed_by
Jacks, Tyler
Location
located_in
Lisa Coussens Laboratory
located in
2013-04-09T15:32:00.472-05:00
nvasilevsky (Nicole Vasilevsky)
2013-04-09T16:01:14.938-05:00
workflow state
Published
nvasilevsky (Nicole Vasilevsky)
Organism or Virus
organism
organism
Mus <mouse, genus>
Mammalia
Rodentia
Organism
non viral organism
Chordata
Vertebrata <Metazoa>
Glires
material_entity
independent_continuant
continuant
entity