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Rhesus macaque

eagle-i ID


Resource Type

  1. Macaca mulatta


  1. Resource Description
    "Viral sequence diversity is the Achilles' heel of traditional vaccine approaches to HIV and poses one of the greatest hurdles to vaccine development. The Sacha laboratory aims to determine which antigens should be targeted to overcome the formidable obstacle of HIV viral sequence diversity. Thus, we are actively exploring three distinct, but related areas of immunity to highly variable pathogens such as HIV: CD4+ T cells While the role of CD8+ T cells in AIDS virus infection is well documented, much less is known about antiviral CD4+ T cell responses. However, understanding the precise immunological role played by CD4+ T cells during retroviral infections will provide insight into the components of an effective immune response and is a key step in facilitating rational vaccine design. Furthermore, CD4+ T cells are able to tolerate extensive sequence diversity in their target epitopes, raising the possibility they might be particularly effective in immunity to hyper-variable pathogens. We are actively pursuing how CD4+ T cells contribute to the control of genetically diverse pathogens like retroviruses. Non-HIV targets for protection: Endogenous Retroviruses: The genome of every human being contains endogenous retroviruses (ERVs), which are the genetic fossil remains of ancient retroviral infections that integrated into germ line cells. Although normally quiescent, ERVs are active and targeted by the immune response during infection with pathogens such as HIV and in disease states like cancer. Because ERV-specific immune responses arise only during pathological processes, they may represent an alternate, stable target for vaccine-induced immunity. We are exploring the role of ERVs in immunity to disease to understand how to exploit these germ-line sequences for protecting the host from viral infection and disease. Elite control A rare subset of infected individuals will contain viral replication to undetectable levels and do not progress to AIDS even without antiretroviral treatment. These rare individuals offer a glimpse into effective anti-AIDS virus immunity. Interestingly, some of these individuals will spontaneously lose the ability to control the virus. We are studying the breakthrough virus in these individuals to delineate correlates of protection from infection with a chronic virus like HIV."
  2. Related Disease
    Human immunodeficiency virus infectious disease
  3. Related Publication or Documentation
    Pyrosequencing Reveals Restricted Patterns of CD8+ T Cell Escape-Associated Compensatory Mutations in Simian Immunodeficiency Virus
  4. Related Publication or Documentation
    CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller.
  5. Related Publication or Documentation
    Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic.
  6. Biological process studied
    Defense response to virus
  7. Location
    Jonah Sacha Laboratory
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016