SynCAM1 (GFAP-DNSynCAM1) mice

eagle-i ID

Resource Type

Properties

1. Resource Description

   Male heterozygous mice that express an astrocyte-specific dominant-negative form of SynCAM1 (GFAP-DNSynCAM1) under control of the glial fibrillary acidic protein (GFAP) promoter on the FvB/N background were bred to either FvB/N or C57BL/6 J wild-type (WT) females. Three independent transgenic lines of GFAP-DNSynCAM1 mice (Lines 27, 42 and 45) were used to generate offspring.

2. Related Disease

   attention deficit hyperactivity disorder

3. Related Publication or Documentation

   Astrocyte-specific disruption of SynCAM1 signaling results in ADHD-like behavioral manifestations.

4. Related Technique

   Behavioral assay

5. Parental Strain Name

   FvB/N×C57BL/6 J

6. Biological process studied

   locomotory behavior

7. Genetic Alteration(s)

   GFAP-DNSynCAM1

8. Phenotype Findings

   Increased activity

9. Location

   Sergio Ojeda Laboratory