eagle-i Oregon Health & Science UniversityOregon Health & Science University
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

SynCAM1 (GFAP-DNSynCAM1) mice

eagle-i ID

http://ohsu.eagle-i.net/i/0000013f-1bf2-1070-f351-2c0e80000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Male heterozygous mice that express an astrocyte-specific dominant-negative form of SynCAM1 (GFAP-DNSynCAM1) under control of the glial fibrillary acidic protein (GFAP) promoter on the FvB/N background were bred to either FvB/N or C57BL/6 J wild-type (WT) females. Three independent transgenic lines of GFAP-DNSynCAM1 mice (Lines 27, 42 and 45) were used to generate offspring.
  2. Related Disease
    attention deficit hyperactivity disorder
  3. Related Publication or Documentation
    Astrocyte-specific disruption of SynCAM1 signaling results in ADHD-like behavioral manifestations.
  4. Related Technique
    Behavioral assay
  5. Parental Strain Name
    FvB/N×C57BL/6 J
  6. Biological process studied
    locomotory behavior
  7. Genetic Alteration(s)
    GFAP-DNSynCAM1
  8. Phenotype Findings
    Increased activity
  9. Location
    Sergio Ojeda Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016