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SynCAM1 (GFAP-DNSynCAM1) mice

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    Male heterozygous mice that express an astrocyte-specific dominant-negative form of SynCAM1 (GFAP-DNSynCAM1) under control of the glial fibrillary acidic protein (GFAP) promoter on the FvB/N background were bred to either FvB/N or C57BL/6 J wild-type (WT) females. Three independent transgenic lines of GFAP-DNSynCAM1 mice (Lines 27, 42 and 45) were used to generate offspring.
  2. Related Disease
    attention deficit hyperactivity disorder
  3. Related Publication or Documentation
    Astrocyte-specific disruption of SynCAM1 signaling results in ADHD-like behavioral manifestations.
  4. Related Technique
    Behavioral assay
  5. Parental Strain Name
    FvB/N×C57BL/6 J
  6. Biological process studied
    locomotory behavior
  7. Genetic Alteration(s)
  8. Phenotype Findings
    Increased activity
  9. Location
    Sergio Ojeda Laboratory
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016