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Core Laboratories at Oregon Health and Science University

This is a summary list of all core laboratories at Oregon Health and Science University . The list includes links to more detailed information, which may also be found using the eagle-i search app.

Advanced Computing Center Core Facility

Summary:

"The mission of the Advanced Computing Center (ACC) at OHSU is to meet the advanced computing needs of the OHSU research, academic, and administrative community by providing a scalable set of advanced computing services that augment and supplement no-cost core services provided to the OHSU Enterprise by the Information Technology Group."

General services offered include an on call systems and database admin available after hours.



Advanced Imaging Research Center

Summary:

The Advanced Imaging Research Center (AIRC) at Oregon Health & Sciences University specializes in generating novel Magnetic Resonance (MR) techniques and technologies for the advancement of biomedical research.

The AIRC at OHSU has as its basic mission the advancement of medical imaging. With this charge it has become a center for cutting-edge research in imaging science. It is a research facility independent of existing departments at OHSU.



Advanced Light Microscopy Core Laboratory

Summary:

This lab offers research scientists access to high-end instrumentation for fluorescence microscopy. We offer support with image acquisition, processing, analysis and presentation.



Assisted Reproductive Technologies (ART) and Embryonic Stem Cell (ESC) Laboratory

Summary:

The Assisted Reproductive Technologies (ART) and Embryonic Stem Cell (ESC) Laboratory provides researchers with nonhuman primate gametes, embryos, follicular cells, embryonic stem cells, and other ART/ESC-related services in support of studies on gamete and follicular development, fertilization and contraception, early embryogenesis, pregnancy initiation, fetal development, stem cell biology, cell-based therapy of human disease, and the creation of disease models in non-human primates.

The Core conducts research projects to investigate new areas of technology for creating or propagating valuable founder animals, including genetically modified and genetically identical monkeys and derivation, characterization, and transplantation of autologous, immunocompatible, pluripotent cells. In addition, the ART/ESC laboratory provides expertise and training in all aspects of the nonhuman primate ARTs and ESCs to scientists around the world.



Bioanalytical Shared Resource/Pharmacokinetics Core Laboratory

Summary:

This resource is available at OHSU for the analysis of small molecules such as drugs and drug metabolites, neurotransmitters, fatty acids and biologically active metabolites of fatty acids, steroids, and natural products . The BSR provides open access to a laboratory where users can prepare and analyze their own samples by HPLC, GC/MS or LC/MS on equipment maintained by Core personnel. In addition, samples can be submitted for complete analysis by Core staff and the Director and Associate Director are available for assay development assistance.



Biochemical Genetics Laboratory

Summary:

The OHSU Biochemical Genetics Laboratory is dedicated to providing specialized laboratory testing and comprehensive diagnostic evaluation of rare and unusual inherited metabolic diseases. Our expertise includes interpretation of results which requires detailed knowledge of the field by individuals specializing in clinical biochemical genetics.



Biomedical Informatics Program

Summary:

The Biomedical Informatics Program (BMIP) provides investigators with state of the art informatics tools and methodologies to support translational researchers. Using a hybrid of collaborative and service approaches, BMIP is continually developing and deploying an array of informatics tools for bench research (bioinformatics), bedside research (clinical research informatics), and translation to practice (medical informatics). BMIP also provides a platform for collaborative and multidisciplinary informatics education and research.

The Biomedical Informatics Program includes two major areas of emphasis:

Translational Bioinformatics - Novel methodology development
Statistical Genetics
Functional Genomics
Clinical Research Informatics
Research Data Warehouse - Using Epic and other clinical data for research
Clinical research data management software
Epic as an interventional tool for research



Biomedical Informatics Shared Resource

Summary:

The BMISR provides expertise in data collection and management to clinical researchers. Through effective trial management and innovative data collection, clinical trial efficiency can be improved and high quality data collected for analysis. This automated data collection, storage and reporting reduce data errors and save time and effort during collection and analysis.
Consultation and services are available during every stage of the research process--from grant proposal writing through research data collection, management and analysis. We can provide custom applications for data collection, management and dissemination using a broad array of technologies and tools. We can help with standalone database applications (such as Access), using scannable paper forms, developing web applications, designing database applications, just to name a few.



Clinical Cytogenetics Laboratory

Summary:

"The OHSU Clinical Cytogenetics Laboratory specializes in high-resolution chromosome analysis. Emphasis has consistently focused on the highest quality preparations in order to provide the patient with the most accurate diagnosis."

Certifications: CLIA; CAP; American Board of Medical Genetics; Clinical Cytogenetics; Medical Genetics



DNA Sequence Analysis Shared Resource

Summary:

We perform DNA sequencing & genomic analysis and RNA/DNA (oligonucleotide) synthesis on a fee-for-service basis. We are happy to consult on your sequence assembly and analysis or other data processing, informatics, and database needs as well.



Electron Microscropy Core

Summary:

Access to EM Core equipment and services is available to all researchers at OHSU. We also provide EM services to non-OHSU institutions and individuals. Our intention is to make services available at reasonable rates. To maximize our time and to minimize costs, researchers may participate in sample preparation, sectioning, and/or EM viewing steps. Training for equipment usage is provided at an hourly rate, and individuals can schedule access to equipment after they are trained. We invite anyone interested in using EM approaches for pilot projects, or ongoing investigations to consult with us on their needs, protocols, services, and cost estimates.



Electronics and Instrumentation Design Core Resource

Summary:

The Electronics & Instrument Design Core Resource provides hands-on design and fabrication of specialized equipment for research projects. Projects involve analog and digital electronics design, microcontroller, software development and optical and embedded processor design. The core director, John Hunt, MSEE, is a senior research engineer and instructor in the Department of Biomedical Engineering, OHSU School of Medicine. OHSU School of Medicine. He has worked as a research engineer at OGI/OHSU since 1980 and has developed equipment for many research projects and departments.



Endocrine Technology Support Core Laboratory

Summary:

The Endocrine Technology Support Core Lab (ETSL) has provided intra- and extramural investigators with analysis of protein and steroid content in blood, as well as in biological tissues and fluids for more than 3 decades.
Principal support functions include provision of routine assays (for most naturally occurring steroid and protein hormones involved in the regulation of reproduction, metabolism, and the central nervous system) and development of new assays (e.g., Multiplex platforms for cytokines and signaling molecules).



Flow Cytometry Shared Resource

Summary:

The OHSU Flow Cytometry Shared Resource (FCSR) has operated as a core resource for OHSU Knight Cancer Institute members since 1996 and provides advanced flow cytometry instrumentation, technical expertise and technical services. The FCSR also provides training in data interpretation, experiment design and routine operation to researchers, offering an additional cost-saving option of doing some of the work themselves. Finally, this resource saves valuable investigator time by analyzing specimens and preparing them, if needed.



Gene Profiling Shared Resource Core Laboratory

Summary:

The OHSU Gene Profiling Shared Resource (formerly the Gene Microarray Shared Resource) functions as a full-service genomics facility serving research scientists and clinicians with services for RNA expression profiling and DNA variation analysis on two microarray platforms, Affymetrix and Illumina and on Applied Biosystems QuantStudio real-time PCR system. We are also now able to provide expression profiling and genome analysis services using Ion Torrent PGM sequencer. Support for RNA isolation and RNA/DNA quality assessment also available.



Histopathology Shared Resource

Summary:

The Histopathology Shared Resource is a College of American Pathologists (CAP) certified and Clinical Laboratory Improvement Amendments (CLIA) accredited core facility that provides investigators with tissue-based services fundamental to the progress of basic, translational and clinical research.

The mission the Histopathology Shared Resource (HSR) is to:

1. Provide investigators with histology services critical for the progress of biomedical research involving studies on research animal and human tissues These services include cryostat sectioning, paraffin- embedding, cell pellet and cytospin preparation, microtome-sectioning, histochemical staining and immunohistochemistry.

2. Provide investigators with consultation and education in regard to best use of histopathology services research protocols, safety issues, and IRB application.



Imaging and Morphology Support Core Laboratory

Summary:

The Imaging and Morphology Support Core of the ONPRC is designed to meet the imaging needs of ONPRC scientists and of the OHSU scientific community by providing state-of-the-art facilities, expertise, assistance and training in the use of advanced light microscopy, image analysis, processing and printing, and laser capture microdissection. Special emphasis is placed on quantitative evaluation of imaging experiments using both stereology and automated image analysis.



Immuno Electron Microscopy Core

Summary:

Imaging center has an excellent physical facility for handling samples for light or electron microscopy. We have a unique Multi-suite dissection, sectioning, and embedding area. This area is equipped with fume hood, two refrigerators, -80 freezer, tissue processors, and surgical instruments. Tissues of interest may be prepared ranging from fresh frozen for fluorescence microscopy to embedding in plastic for electron microscopy. We have or have access to; cryostats, paraffin microtomes, vibratomes, and ultramicrotomes.

The EM core is experienced in many specialized electron microcopy techniques. These include immunogold labeling, negative staining.

We have two FEI transmission electron microscopes, a Morgagni, and a Techni 12, both with AMT digital cameras for micrograph production.



Immunology Support Core, Cellular Immunology Unit

Summary:

"The CIU offers all the study organization and technical expertise developed at the Louis Picker Lab to researchers whose questions require obtaining and processing monkey immunological samples, and/or utilizing cytometry to assay phenotype of CFC/ICS information." The CIU was originally developed as part of the Bill & Melinda Gates foundation CAVD (Collaboration for AIDS Vaccine Discovery) consortium.



Immunology Support Core, Flow Cytometry Unit

Summary:

The mission of the Immunology Support Core (ISC) is to develop and provide a wide range of state-of-the-art services, assays, and training in support of NIH-sponsored immunology research involving nonhuman primates (NHP).



In Vivo Optical Imaging Center

Summary:

The IOIC is located in Cardiac Imaging Laboratory on the first floor of the Biomedical Research Building (BRB). The laboratory was established through a Shared Instrument Grant (PI: Michael Deininger) but is maintained through user fees. The core facility includes the IVIS Spectrum optical imaging camera housed in a light-tight housing, rat and mouse imaging platforms for multi-subject simultaneous acquisition, an integrated inhaled anesthesia system, and advanced analysis software. A key component of the IOIC is the ability to operate either independently or under the guidance and supervision of core personnel. Independent use of the system requires that investigators undergo training that is offered every 2 months or on an ad hoc basis. All analysis will be charged on an hourly basis and is graduated according to the level of service (independent or supervised).



Investigator Support and Integration Services

Summary:

The mission of the Investigator Support and Integration Services (ISIS) program is to facilitate clinical and translational research at OHSU and the Portland VA Medical Center. ISIS works with these institutional partners to streamline study start-up and management processes and related administrative and compliance processes and provide pre-award and regulatory services to investigators. ISIS administers the Human Subjects Protection Program of the Clinical and Translational Research Center (CTRC) to maximize the protection of human subjects involved in OCTRI projects. The OHSU Clinical Trials Office, a unit within ISIS, provides study start-up services and negotiation of contracts for OHSU industry-sponsored clinical trials.



Layton Aging & Alzheimer's Disease Center Education Core

Summary:

The Education and Information Core of the Layton Aging & Alzheimer’s Disease Center develops and carries out a wide range of educational programs to:

* Increase public awareness and understanding of Alzheimer's Disease research,
* Aid in the recruitment of subjects for research studies, and
* Improve care and quality of life for persons with dementia and support their family caregivers.

Our educational activities include:

* Training for health care professionals which include seminars and lectures and we also provide “hands-on” experiences for medical students,
* Community education on Alzheimer's disease and related dementia disorders,
* Workshops on doctor – patient communication for families and caregivers,
* Collaboration with community organizations and groups to promote awareness of the disease and publicize research activities, a particular focus is underserved populations including rural communities and minority groups,
* Collaboration with other organizations that serve patients and families, e.g., the Alzheimer’s Association and other state and local agencies that serve the elderly and the loved ones who care for them, and
* Distribution of printed material that provides topical information on a variety of subjects related to Alzheimer’s disease and dementia and how best to provide quality of life to those with the disease.
* A newsletter, Aging & Alzheimer's Update, which is published twice per year.
The Education Core administers the Oregon Income Tax Check-off Alzheimer's Research Fund in collaboration with The Oregon Partnership for Alzheimer's Research, a community advisory committee.



Layton Alzheimer's Disease Center Biomarkers & Genetics Core Lab

Summary:

In cooperation with the Data and Clinical Cores at the Layton Center, the Biomarkers and Genetics Core generates and maintains biomarker data for select biomarkers which have established roles in the characterization of subjects with or at risk of dementia. Biological markers of brain aging, dementia risk, and neurodegeneration have the potential to accelerate the identification of disease mechanisms and treatment strategies. "Biomarkers" may include genes, proteins, or other metabolites, and may be identified in DNA, cerebrospinal fluid (CSF), or plasma. Apolipoprotein E (APOE) genotype is generated for all research subjects. Sub-groups of subjects have other types of biomarker data. Many subjects have had genome-wide SNP data generated.

In order to foster collaborative research as well as expand resources and expertise, samples (DNA, CSF, and plasma) and data are distributed to qualified investigators worldwide. Most of these researchers are pursuing the causes and modifiers of dementia. Data and samples are collected from well characterized research subjects including the healthy elderly and dementia patients.



Layton Alzheimer's Disease Center Clinical Core

Summary:

The Oregon Alzheimer’s Disease Center’s (OADC) Clinical Core program, directed by Dr. Jeffrey Kaye, performs longitudinal studies of the natural history of brain aging and Alzheimer's disease in patients and healthy control volunteers.

These studies which are performed through standardized neurological, neuro-psychological, and brain-imaging assessments are carried out in the Alzheimer's Disease and Memory Assessment Clinics as well as through community-based assessments conducted in the homes of study volunteers.

The Layton Center Neuroimaging Lab conducts brain-imaging MRI brain scans to assist in diagnosis of brain disease. Typically, MRI images are taken from three different planes. These planes are known as the coronal plane, sagittal plane and the axial plane. Each series of MRI images is named after the plane from which they were obtained.

The Clinical Core’s research is focused on preclinical and early Alzheimer’s disease (AD) yet is also poised to participate in other relevant new research as it arises. The OADC Clinical Core recruits, assesses and follows individuals from population groups at high risk for dementia such as: the healthy “oldest old”, subjects with family history of AD, and subjects with Mild Cognitive Impairment (MCI).

Research with underserved populations
The Oregon Alzheimer’s Disease Center also maintains two Satellite programs to enhance understanding of underserved populations:

The Klamath Exceptional Aging Project (KEAP) is a community-based study of brain aging being conducted in Klamath Falls.

The African American Dementia and Aging Project (AADAPt) s a Portland-based cohort of 100 African American seniors.



Lipid-Atherosclerosis Laboratory

Summary:

The OHSU Lipid Lab offers precise determination of lipids and specialized lipid metabolites not routinely available in general hospital clinical labs or elsewhere in Oregon. Currently, the OHSU Lipid Lab is the only laboratory on the West Coast that does sterols.



MRI Support Core Laboratory

Summary:

The magnetic resonance imaging (MRI) core provides ONPRC investigators with equipment and assistance to perform MRI exams of sedated NHP subjects.



Massively Parallel Sequencing Shared Resource

Summary:

The OHSU Massively Parallel Sequencing Shared Resource (MPSSR) was founded in 2009 with the mission of providing high quality, cost efficient short read sequencing services. The intent of the MPSSR is to offer state of the art sequencing for a variety of protocols - including genome resequencing, transcriptome analysis, miRNA analysis, and prometer analysis via ChIP-seq. The goal of the MPSSR is to help investigators examine the genetic profiles that underlie disease predisposition and to explore the fundamental operations of biological systems.



Methamphetamine Abuse Research Center Animal Core Component

Summary:

Three of the MARC's research components (5, 6, and 8) include experiments with lines of mice bred to have special genetic traits. The animal core supports these components by purchasing, testing, breeding, maintaining, and distributing these animals within the center.

The core will breed special mouse lines F1 and F2 that are descendents of C57BL/6J (B6) and DBA/2J (D2) inbred strains. For Components 5 and 6, the animal core will also produce independent sets of replicated mouse lines selected for high and low tendencies toward methamphetamine drinking and for high and low methamphetamine-induced sensitization.

In addition, the core is developing new behavioral-testing procedures and maintaining a database that will track individual animals and post their trait data for all MARC investigators to utilize.



Molecular Virology Support Core

Summary:

The overall goal of the Molecular Virology Support Core (MVSC) is to advance the efforts of the Oregon National Primate Research Center (ONPRC), the Vaccine and Gene Therapy Institute (VGTI), and collaborative research programs focused on nonhuman primate (NHP) infectious disease models and those using viral vectors as tools to modify genes or deliver macromolecules through provision of expertise, reagents, standardized assays, and training in the use of infectious viral agents in their research programs.



Molecular and Cellular Biology Core Laboratory

Summary:

The Molecular and Cellular Biology Core provides services, reagents and training for all aspects of molecular biology and cell culture. Services include DNA sequencing, real-time PCR, genotyping, robotic RNA and DNA purification, monkey-specific cDNAs, and customized media and buffers for cell culture. The core also produces lentiviral vectors for cDNA and shRNA delivery. Core personnel assist researchers in maintaining and storing cell lines. The core makes available state-of-the-art equipment, including a 969capillary DNA sequencer, realtime qRT-PCR platforms, and fluorometers for cell-based kinetic analyses..



Monoclonal Antibody Core Laboratory

Summary:

The VGTI Monoclonal Core offers two basic services: the generation of new monoclonal antibodies and the scaleup production and purification of antibody from existing cell lines (a stand -alone phase IV).



Neuropathology Core

Summary:

The Neuropathology Core of the Layton Center for Aging and Alzheimer’s Disease Center is dedicated to studying, through autopsy, the brains of individuals who have been followed longitudinally in the Oregon Alzheimer’s Disease Center Clinical Core.

Requests for tissue from the Oregon Brain Bank should be directed to Dr. Randall Woltjer. Dr. Woltjer will be glad to communicate with investigators regarding their tissue needs and to assist them in identifying suitable materials for their studies. Material Transfer Agreements between the requesting and sending institutions are needed before shipment.



Nuclear Magnetic Resonance Core Facility

Summary:

A facility that uses a state-of-the-art NMR spectrometer to verify or determine the structure of organic molecules. Housed in the Department of Physiology and Pharmacology, it is designed to exploit the power of designed small molecules as probes of protein and cellular function and to provide the foundation for the development of prototypic therapeutic agents.



Oregon Clinical & Translational Research Institute Bionutrition Unit

Summary:

The Bionutrition Unit provides nutrition, body composition, and energy expenditure services. Bionutritionist and research kitchen staff are highly experienced and trained to assist investigators with the design and implementation of research meals, feeding studies, and related research. The Bionutrition Unit also provides a variety of energy expenditure and body composition measurement services using a range of equipment.



Oregon Clinical & Translational Research Institute Core Laboratory

Summary:

The OCTRI Core Laboratory is specifically designed and equipped to perform both basic and specialized research assays and sample processing in support of translational research studies and trials. Laboratory staff have extensive experience in the performance of a wide variety of analytical and genetic based assays and procedures.



Oregon Stem Cell Center Monoclonal Antibody Core

Summary:

The Oregon Stem Cell Center Monoclonal Antibody Core is focused on developing monoclonal antibodies that aid investigators in the identification and isolation of novel stem and progenitor cell populations. To enable isolation of live stem cells, personnel within the Monoclonal Antibody Core develop monoclonal antibodies directed against cell surface antigens. Personnel within the laboratory are highly skilled in all aspects of monoclonal antibody generation and characterization, and work closely with investigators throughout the entire immunization, fusion, and screening process. The monoclonal antibody core offers a full complement of services related to the development of monoclonal antibodies.



Proteomics Shared Resource Core Laboratory

Summary:

The OHSU Protemics Shared Resource facility was established to make state-of-the-art mass spectrometry based protein analysis analytical capabilities available to the biomedical research community at OHSU.



Research Cytogenetics Core Laboratory

Summary:

A fee-for-service cytogentics laboratory available to genetics researchers to assist in development and execution of cytogenetics experiments for research purposes. Through rigorous standardization of protocols and customized experiment development, the OHSU Research Cytogenetics Core Laboratory provides high quality metaphase and interphase cytogenetic data to the OHSU research community. Services are also available to non-profit and commercial investigators located in Oregon and elsewhere.



Transgenic Mouse Model Shared Resource

Summary:

Currently, the transgenic facility is generating transgenic and knock-out mice, cryopreserving mouse embryos as well as performing various other services. We are available for consultations and providing letters of support to investigators.



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